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Exploring GLP-1 Agonists: A Game Changer for Weight Loss and Chronic Pain?

This is the 3rd episode in the ongoing series on obesity and chronic pain continuing with a discussion on GLP-1 agonists and their impact on chronic pain, specifically fibromyalgia and osteoarthritis. The role of GLP-1 agonists like semaglutide in managing diabetes and obesity, their mechanisms of action, and clinical applications is discussed. A recent study from the New England Journal of Medicine detailing the effects of semaglutide on weight loss and osteoarthritis pain is analyzed, highlighting significant improvements in patients with obesity and knee osteoarthritis. The importance of long-term use, potential side effects, and the need for an integrated approach incorporating diet and exercise are also discussed. The episode concludes with the anticipation of next week's guest, Dr. Michael Greger, who will discuss the benefits of a whole food plant-based diet as an alternative to GLP-1 agonists.

00:00 Introduction to the Podcast and Weight Loss Series
00:55 Exploring GLP-1 Agonists
02:05 How GLP-1 Agonists Work
03:42 Clinical Applications and Benefits
04:19 Challenges and Considerations
09:18 GLP-1 Agonists and the Gut Microbiome
11:55 Effectiveness of GLP-1 Agonists
18:10 Study on Semaglutide and Osteoarthritis
30:10 Conclusion and Next Episode Preview

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When I started this podcast—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That’s why I created this space: to offer education, validation, and hope. If you’ve been told fibromyalgia “isn’t real” or that it’s “all in your head,” know this—I see you. I believe you. You’re not alone. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you’ll find trusted, evidence-based insights here, drawn from my 28+ years as an MD.

Please remember to talk with your doctor about your symptoms and care. This content doesn’t replace personal medical advice.*

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