We will examine the positive and negative controls in the milestone article of the Nobel Laureates. The article shows us one of the best examples of how to use positive and negative controls in life-science experiments. We will compare a total of eight figure panels. And we will learn important lessons from them, for designing experiments and for reading figures. This episode will be Part 1 of a summary of control experiments.       

Here are the links to the Milestone Article 1  (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.     

• DOI: https://doi.org/10.1016/j.immuni.2005.06.008
• PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf
• PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/

   
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