Literally! With Rob Lowe Creators & Guests

Robert Hepler Lowe is an American actor and director. He made his acting debut at the age of 15 with ABC's short-lived sitcom A New Kind of Family (1979-1980). He worked in the first four seasons of NBC's The West Wing and recently starred in later seasons of Parks and Recreation.

Hayley Arceneaux is a St. Jude Children's Research Hospital physician assistant, bone cancer survivor and commercial astronaut. She joined billionaire Jared Isaacman on SpaceX's first private spaceflight Inspiration4 launched on September 15, 2021. At age 29, she became the youngest American in space.

Busy Philipps is an actress.

James Burrows, born, December 30, 1940, is an American television director and producer celebrated as one of the most successful and influential figures in sitcom history. He co-created and directed many episodes of the iconic show "Cheers," and has directed episodes of other legendary series like "Friends," "Will & Grace," and "The Big Bang Theory." Burrows' career spans decades, during which he has directed over 1,000 episodes of television, earning multiple Emmy Awards and a reputation for his masterful understanding of comedic timing and ensemble casts. His contributions have shaped the landscape of American television comedy.

Marc Andreessen is an entrepreneur, investor, and software engineer.

Dermot Mulroney is an actor.

George Stephanopoulos is a political commentator, and host of This Week.

Calogero 'Chazz' Palminteri is an actor, screenwriter, producer, and playwright.

Mckenna Grace is an actress.

Adam Carolla is an American comedian, radio personality, actor, and podcaster known for co-hosting the radio show Loveline and his popular podcast The Adam Carolla Show. Carolla gained early fame with the success of Loveline, followed by his co-hosting of The Man Show and Crank Yankers. A stand-up comedian and author, Carolla has written several New York Times bestselling books.

Oprah Winfrey is a media executive, actor, talk show host, television producer, and philanthropist. She is best known for her talk show "The Oprah Winfrey Show," which aired nationally for 25 years. Winfrey is currently the host of multiple shows, including ''Oprah Super Soul', 'The Oprah Winfrey Show: The Podcast' and 'Oprah's Master Class: The Podcast'.

Jeanie Buss is a sports executive, controlling owner, and president of the Lakers of the National Basketball Association.

Hilary Ann Swank is an actress and producer. She has received two Academy Awards, two Golden Globe Awards, two Critics Choice Awards, and a Screen Actors Guild Award.

Mike Myers is a celebrated comedian, actor, and writer known for his iconic roles and comedic genius. Born in Scarborough, Canada, Myers gained fame as a cast member on "Saturday Night Live" (1989-1995), where he created memorable characters like Wayne Campbell and Dieter. He achieved global success with the "Austin Powers" series (1997-2002) and the "Shrek" franchise, where he voiced the titular character. Myers' comedic talent and versatility have made him a beloved figure in entertainment. Recently, he returned to television with the Netflix series "The Pentaverate" (2022), showcasing his enduring appeal and creativity.

Seth MacFarlane is an actor, voice artist, animator, filmmaker, and singer. He also wrote, directed, and starred in the films Ted, its sequel Ted 2, and A Million Ways to Die in the West.

Fortune Feimster is a writer, comedian, and actress.

Daryl Davis is a blues musician, activist, author, actor, and bandleader.

Jonathan Niven Cryer is an American actor, comedian, and television director. He made his motion picture debut as a teenaged photographer in romantic comedy No Small Affair. His breakout role came, playing "Duckie" in the John Hughes-written film Pretty in Pink. He later wrote and produced the independent film Went to Coney Island on a Mission from God... Be Back by Five.

David Walter Foster is a Canadian musician, record producer, composer, songwriter, and arranger.