0:01

Welcome to Pushing the Limits

0:03

with your host, Lisa Tarmity, where

0:05

it's all about health optimization, anti-aging,

0:08

longevity and being the very best

0:10

you can be. Port you by

0:12

Lisa Tarmity.com. Well, hi everyone

0:15

and welcome into Pushing the Limits.

0:17

Today, I'm super, super excited because

0:19

I get to interview Dr. Rod

0:21

Klaikim. and I get to introduce

0:24

you to our new product from

0:26

our biotech company Avon Labs. Now

0:28

I've been talking about it for

0:30

a few months on the podcast and

0:32

it's taken over two years of

0:34

formulation work working with

0:36

a world-class scientific advisory team

0:39

to bring this formulation to the

0:41

market and today we're doing an

0:43

interview on one of the ingredients

0:46

in our formulation called immune defense

0:48

protein. formulation was something that

0:50

I identified in the market

0:52

as having been missing and I

0:55

really wanted something that would help the

0:57

aging of the immune system. After all

0:59

my research over the last few years

1:01

I've come to realize that the immune

1:03

system is at the basis of all

1:06

of the hallmarks of aging. it affects

1:08

all of them, all 14 of them.

1:10

So as a foundational longevity product, I

1:12

could not find out anything out in

1:15

the market that was going to help

1:17

the aging, or something called immunosinescent,

1:19

which is the aging of

1:21

the immune system. And it's

1:23

why as we get older,

1:25

we become more prone to

1:27

things like cancer, not responding

1:30

well to infections, pathogens, and

1:32

autoimmunity, and all of those

1:34

sorts of problems. And so I

1:36

set out. on a journey to found

1:38

our company, Avon Labs, and then to

1:40

work with a really amazing team of

1:43

people to bring you this amazing

1:45

formulation. It's taken over two years

1:47

of work to get to this

1:49

point, but now we have in

1:51

our hot little hands our first

1:53

product called Rejuvenate. Now companies

1:56

called Avon Labs, A-E-V-U-M, and

1:58

the product is. rejuvenate for

2:01

obvious reasons. And this was a product

2:03

that's going to help give you back the

2:05

function of a younger immune system. And

2:07

we're going to be doing a deeper

2:10

dive in the coming months into various

2:12

aspects of this formulation. But today we're

2:14

doing an interview with Dr. Rod Klaykim,

2:16

who is the CEO and founder of

2:18

Quantek. And they've done over 15 years

2:21

with a clinical research into something

2:23

called immune defense protein, which

2:25

is one of the cornerstones of

2:27

our formulation. and our inflammation

2:29

is really targeting gut

2:31

health, it's targeting leaky

2:33

gut, leaky barriers actually in

2:36

the body, so anything that's

2:38

exposed to the outside world,

2:41

it helps with immunogrobulins transfer

2:43

factors, helps antimicrobial, anti-oxidant, it

2:46

is... got immunogobulins, it is

2:48

a really powerful combination and

2:51

I really wanted this for

2:53

my mom because I wanted

2:56

something that even fragile, sick,

2:58

older people can take safely and

3:00

it's going to give them back. the

3:02

function of a better immune system and

3:05

I've seen just anecdotally in her case

3:07

and in my case our lymphocyte counts

3:09

go up which is something that you

3:11

fight with as you get older that

3:13

this starts to deteriorate. So I'm going

3:15

to pass over now to Dr. Rod

3:17

Klachem to introduce immune defense protein which

3:20

is just one of the four ingredients

3:22

that we have in our formulations

3:24

so I hope you enjoy the

3:26

show and if you're wanting to

3:28

get some rejuvenate you can go

3:30

over to Lesitamity.com hit the shop

3:33

button. and there you will find

3:35

Avum Labs rejuvenate product and we'll

3:37

put the link of course in the

3:39

show notes below. You can also

3:41

visit our dedicated website which

3:44

is Avum Labs.co.nz and depending

3:47

on when you listen to this

3:49

there may be a discount that's

3:51

available if you put in the

3:53

code Avum on my website you

3:55

should get a discount depending on

3:58

when you listen to this. But

4:00

in any case, this is a

4:02

foundational longevity and immune system product

4:04

that's going to help with everything from

4:06

gut health to autoimmune immunity to cancer

4:09

surveillance to the barriers, all of these

4:11

sorts of things. So enjoy this deep

4:13

dive into immune defense proteins. One

4:15

of the key factors with Dr. Rod

4:18

Clekham. Well,

4:21

hi everyone and welcome into Pushing the

4:24

Limits today. It's fantastic to have you

4:26

with me. Now I have Dr. Rod

4:28

Klaken with me. Welcome to the show,

4:30

Dr. Rob. It's fantastic to

4:32

have you. Thank you for having me, Lisa.

4:34

It's a pleasure to be. It's really exciting.

4:36

We're going to be diving into a

4:39

ingredient today. A molecule today. What would

4:41

you call it? You call it

4:43

the molecule? We call it ingredient.

4:45

Well, ingredient, it's more than one

4:48

molecule as you'll find out

4:50

here shortly. So Dr. Rod

4:53

is the founder of Quantic.

4:55

along with some colleagues. And

4:57

Quon Tech has been developing

5:00

a novel way protein with

5:02

50 bio-actives in it called

5:05

immune defense protein. And I've

5:07

been super excited to learn

5:10

about this. You guys listening

5:12

out there all know that

5:14

I'm a longevity, anti-aging, health

5:17

optimization, obsessed person. And this

5:19

came on to my radar

5:21

through a friend of mine,

5:24

Peter Leiki. Thanks Peter for bringing

5:26

this to our attention and we're

5:28

going to be using this hopefully

5:30

soon in one of our formulations

5:32

at Avon Labs so we're really

5:34

really excited about this so we

5:36

thought we'd get Dr. Rodd on

5:39

to explain straight from the scientist's

5:41

mouth really what is immune defense

5:43

protein and why am I so

5:45

excited about it? So Dr. Rodd before

5:48

you answer that though give us a

5:50

bit of a background on yourself and

5:52

introduce yourself to the audience. background on

5:54

myself. Well, as you can tell from

5:57

my accent, I'm American, but I've been

5:59

living in New Zealand for, oh

6:01

geez, 20, it'll be 25 years

6:03

in June. So, but my background

6:06

is all in the dairy industry,

6:08

so I consider myself a dairy

6:10

expert from, really from the cow

6:13

through the milking process, through the

6:15

processing, and now into, as you'll

6:17

find out today, the finished product,

6:19

finished ingredient, finished product, and too.

6:22

So, dairy's my game. I got

6:24

my, I did my PhD in

6:26

the 90s at UC Davis in

6:28

California. And at that time we

6:31

were developing the world's first progesterone

6:33

biosensor to put on farms to

6:35

measure progesterone and milk to help

6:37

farmers manage their reproduction more efficiently.

6:40

So that's really the tech part

6:42

of dairy that got me started

6:44

to be where I am today.

6:46

Yeah, the thing that most people

6:49

would never think about of some

6:51

of the technologies that goes into

6:53

the dairy industry and to the

6:55

food side of it and also

6:58

that type of side of it

7:00

and you know farming is so

7:02

much more complex than it used

7:05

to be when you used to

7:07

go out and your gun boots

7:09

and milk or cow and have

7:11

the milk on the table at

7:14

breakfast. It's a little bit more

7:16

than that now. Oh you still

7:18

do that. You still do that.

7:20

Yeah, some places. And that's really

7:23

fascinating. I always think that sometimes.

7:25

the animals get more accurate measurements

7:27

things testing done than the humans

7:29

do a lot of the time.

7:32

Certainly more frequent that's for sure.

7:34

Yeah more frequently in the in

7:36

the farmers know what is going

7:38

on with their herd more than

7:41

we know what's going on in

7:43

their own bodies half the time

7:45

and trying to get a blood

7:48

test is sometimes a bit of

7:50

a mission for ourselves. But without

7:52

getting off topic so dairy is

7:54

your area of expertise. And then

7:57

you, how did you discover immune

7:59

defense protein? What was that process?

8:01

What were you looking at there

8:03

that you were trying to find?

8:06

Yeah, well, we weren't trying to

8:08

find anything. So we, back in

8:10

the early 2000s, we were the

8:12

first company to bring robotic milking

8:15

to New Zealand. And the two

8:17

things I was charged with when

8:19

I was asked to come to

8:21

New Zealand for work was to

8:24

look at on-farm sensors and automation

8:26

and on-farm fractionation of milk components.

8:28

And about three or four years

8:30

into it, we had commercialized some

8:33

on-farm milk components sensing technologies like

8:35

on-farm somatics help count measurement for

8:37

mastitis, on-farm fat and protein for

8:40

milk quality and feeding efficiency and

8:42

those sorts of things. And when

8:44

we brought the robotic milking system

8:46

into New Zealand, we were milking

8:49

one cow every 10 minutes. And

8:51

so you can imagine the milk

8:53

flow rate was pretty low, as

8:55

opposed to 200 cows in two

8:58

hours, you know. And so we

9:00

started looking at ways we could

9:02

fractionate lactaferen on farm. Lactaferen in

9:04

the early 2000s was probably as

9:07

big as it is today, but

9:09

it was a lot newer of

9:11

an ingredient in milk that was

9:13

pretty well understood. There was an

9:16

international conference for Lactafarin that's run

9:18

biannually, that's still run today. And

9:20

our being technological people, we thought,

9:22

well, if we could figure out

9:25

a way to fractionate the Lactafarin

9:27

on farm cow side, maybe we

9:29

could add some efficiencies in there,

9:32

return some value behind the farm

9:34

gate, and who knows, maybe even

9:36

increase the quality. of the lactiferin

9:38

as opposed to being extracted in

9:41

the factory. And so that's what

9:43

we did. We built the world's,

9:45

when I say we, it was

9:47

a PhD student at the University

9:50

of Waikato who did this, built

9:52

the world's first on-farm lactiferin fractionation

9:54

robot. Wow. So while one cow

9:56

was being milked, lactiferin was being

9:59

extracted right beside the machine. Wow.

10:01

Fast forward to sort of 2005-67,

10:03

we decided we were going to

10:05

commercialize this and we started talking

10:08

to dairy companies and the dairy.

10:10

companies just didn't want a bar

10:12

of changing the centralized dairy processing

10:15

model to having on-farm pre-processing. Except

10:17

for the fact they said if

10:19

you could prove to us that

10:21

the on-farm quality is better than

10:24

what we get out of the

10:26

factory, then you have an audience.

10:28

And so we hired my co-founder,

10:30

Dr. Judy Bragger, in 2005-6, to

10:33

start doing just that. looking at

10:35

the quality of the lactafan and

10:37

we were pulling out on farm

10:39

versus the factory. And there is

10:42

definitely a difference in the quality.

10:44

It probably wasn't measurable enough to

10:46

justify the whole switch in the

10:48

shake-up in the dairy industry for

10:51

processing. But in so looking at

10:53

the antichu started out looking at

10:55

the antimicrobial properties of lactafan and

10:57

she kept discovering that the more

11:00

and more she purified the lactafan,

11:02

the less and less. the antimicrobial

11:04

activity became. And that was intriguing.

11:07

I guess that was the aha

11:09

moment. So we weren't actually looking

11:11

to discover IDP. We were trying

11:13

to characterize the quality of the

11:16

lactofan. And long story short, that

11:18

that discovery was this 50 plus

11:20

sweet of way proteins, what we

11:22

now call IDP, are all in

11:25

milk to protect the cow from

11:27

infection and inflammation. and it takes

11:29

all of them together in roughly

11:31

the same ratio as they are

11:34

in milk in the first place

11:36

in order to have their maximum

11:38

antimicrobial activity. And so that's where

11:40

IDP came from. We filed a

11:43

patent on that synergistic effect of

11:45

all of the bioactive weight proteins

11:47

in milk. Fortunate for us, dairy

11:49

companies already had a way to

11:52

extract them from milk because they're

11:54

extracted as part of the lack

11:56

of fern process. We just characterized

11:59

what we wanted them to do,

12:01

turn that into a freeze-dried ingredient,

12:03

and start. started looking at ways

12:05

to use that freeze dried ingredient

12:08

in both animal and human health

12:10

applications. Wow. And so give us

12:12

a bit of a background on

12:14

the lactiferin itself because not everyone

12:17

is familiar with the benefits of

12:19

lactiferin in general. Can you give

12:21

us a bit of an overview

12:23

of lactiferin itself? Well, what lactiferin

12:26

can't do is probably the shorter

12:28

list. Yeah, yeah, exactly. It's pretty.

12:30

amazing milk protein. Its primary function

12:32

is iron binding, so that's where

12:35

the fern part comes from it.

12:37

Lactaferrin has a heem group, much

12:39

like the hemoglobin in your blood.

12:41

And so lactaferrin binds iron, so

12:44

it can do a number of

12:46

things through that core bioactivity. It

12:48

can, some bacteria require iron to

12:51

metabolize. So by lactaferrin binding it,

12:53

it can steal the iron from

12:55

the bacteria. That's one example of

12:57

what Lactifering can do. Lactofering can

13:00

carry iron in your body to

13:02

places where it's needed. So it

13:04

can't just doesn't only sequester iron,

13:06

it can actually deliver iron. And

13:09

then, I mean, I'm going to

13:11

shorten this list because we could

13:13

be here all day talking about

13:15

Lactifering. It's got five years of

13:18

biannual conferences dedicated to the thing.

13:20

Right. Yeah, it's been shown to

13:22

have antimicrobial properties, antiviral properties, anti-inflammatory

13:24

properties. A lot of the properties

13:27

that I'll talk about with you

13:29

today, Lisa, on IDP, is the

13:31

same as lactiferin because lactiferin is

13:34

the most abundant protein in IDP.

13:36

It has IDPS a minimum of

13:38

40% lactiferin in it. Wow, wow.

13:40

Okay, so, so, electriferin is also

13:43

a trans glycosylating agent. I recently

13:45

found out from Dr. Sandra Kaufman.

13:47

Did you know that one? No,

13:49

I didn't. Well, this is a,

13:52

there is a, there is a,

13:54

I love it. So I interviewed

13:56

Dr. Sandra Kaufman last week. wonderful

13:58

woman who's actually an an anesthesiologist

14:01

a pediatric anesthesiologist but she's written

14:03

a book called the Kaufman Protocol

14:05

and One of her favorite ingredients

14:07

or molecules is lactiferin. And she's

14:10

a big fan of eating donuts,

14:12

you see, herself. Like she's had

14:14

a problem with donuts. So she's

14:16

always been trying to find ways

14:19

for getting rid of advanced location

14:21

in products is one of the

14:23

areas that she specialised in. And

14:26

funnily enough, she came across research

14:28

that lactiferin actually sucks up excess,

14:30

you know, advanced glycation in products

14:32

and can be very beneficial. So

14:35

when she eats. don't, she has

14:37

some lack to fear and with

14:39

it along with a number of

14:41

other... Oh, that's... that information is

14:44

gold Lisa. I love it. You'll

14:46

have to listen to the actual

14:48

interviews. So yeah, not that I'm

14:50

promoting everyone go out and eat

14:53

donuts. What she's trying to do

14:55

there is to lower the sugar

14:57

levels in the body so you

14:59

don't get these terrible, you know,

15:02

advanced glocation end products which really

15:04

are really, really damaging to the

15:06

body. And so that was a

15:08

part of her strategy and Lactifer

15:11

had just happened to pop up

15:13

in that conversation. So I was

15:15

like, uh-huh. Oh, very interesting. Okay.

15:18

I'm glad I've been able to

15:20

teach you something to teach you

15:22

something today. That's funny. So electaferein

15:24

is, well, if we, colectaferein is

15:27

a really important piece of this,

15:29

but IDP is far more than

15:31

lactaferein. The other, one of the

15:33

major pieces is lactoporoxidase. Can you

15:36

talk to electoporoxidase and what that

15:38

is? Yeah, well, let me just

15:40

back up a second and I'll

15:42

describe in a nutshell what IDP

15:45

is. instead of talking about the

15:47

individual proteins, let me just explain

15:49

what it is. So milk is

15:51

85% water, only 15% solids, and

15:54

that 15% solids roughly divided between

15:56

fat, milk, sugar, or lactose and

15:58

protein. And of that 5% protein

16:01

fraction, 85% of the protein is

16:03

casing. So the protein that's used

16:05

in cheese. And only 15% of

16:07

that 5% is way protein. So

16:10

that's the protein that gets lost

16:12

in the cheese making process. Not

16:14

a herd curds in way. It's

16:16

the way that goes. Now 85%

16:19

of the way is two particular

16:21

way proteins that we call inactive

16:23

way proteins. alphylactylactylbumen and betaylactylobulin. And

16:25

those proteins are great sources of

16:28

amino acids. So that's why whey

16:30

is spray-dried and put into sports

16:32

groups. You know, there are sources

16:34

of amino, you probably used heaps

16:37

of whey proteins in your career.

16:39

Yeah, some, some, not that much

16:41

actually. Oh, right. But some, yeah.

16:43

Yeah, well, like I said, they're

16:46

inactive, those two proteins, but they're

16:48

great sources of amino acids. It's

16:50

the small percentage, the 15% of

16:53

the wave fraction, that we call

16:55

the bioactive wave fraction. And it's

16:57

in that fraction that we now

16:59

know there's over 50 individual bioactive

17:02

way proteins. And it's that whole

17:04

fraction together that we call IDP.

17:06

You've got a wonderful graphic on

17:08

your website, actually, with the, you

17:11

know, the big circle, that's the

17:13

milk, and then 85% water, and

17:15

then 15% protein, and that's broken

17:17

to case. And that really, so

17:20

it gives you a bit of

17:22

a pictorial sort of story, if

17:24

you like, of how you've got

17:26

down to this IDP. And I

17:29

think it's like, one gram of

17:31

IDP per 10 litres of milk,

17:33

is that great? That's right. That's

17:35

right. So on average every 10

17:38

lit. Every 10 liters of normal

17:40

milk contains one gram of normal

17:42

milk contains one gram of IDP

17:45

contains one gram of IDP. So

17:47

going out and having a glass

17:49

of milk today is not going

17:51

to cut the mustard ready so

17:54

to speak. No, no, you're going

17:56

to have to drink a lot

17:58

of milk to get the amount

18:00

of IDP that you... need to

18:03

have a proper active dose of

18:05

IDP and of course if you

18:07

drink that much milk you're also

18:09

drinking all of the other stuff

18:12

that milk provides too which aren't

18:14

delicious but in excess of course

18:16

you know you don't want to

18:18

do that. Yeah and generally we've

18:21

got it you know a lot

18:23

of sugar and a lot of

18:25

fat in our diet. Anyway we

18:28

probably don't want to have 10

18:30

liters worth of milk in order

18:32

to get the one. No it's

18:34

great. If you're eating that many

18:37

don't it's less. Yeah, no, definitely.

18:39

Okay, so what does the word

18:41

bioactive mean? Can you explain that

18:43

to bioactive proteins? What do you

18:46

mean by that when you say

18:48

that? Right, okay. So I just

18:50

explained that the two way proteins,

18:52

beta-lactylobiuman, are what we call non-bioactive

18:55

proteins. So they don't do anything

18:57

those two proteins except for... They're

18:59

just proteins, they're globulin proteins, so

19:01

they can bind to things and

19:04

pull things together, but they're a

19:06

nutritious source of amino acids when

19:08

they break down in the gut.

19:10

What we mean by bioactive is

19:13

things like enzymes, which can, they

19:15

have, the proteins have a tertiary

19:17

structure, a three-dimensional structure, that can

19:20

grab onto substrates in a fluid

19:22

and... transform them into something that

19:24

kills a bacteria. Are they filling

19:26

them into something that disrupts an

19:29

inflammatory pathway? You know, so they

19:31

have a biological functionality associated with

19:33

them. And so that's what we

19:35

mean by bioactivity. And at Quantec,

19:38

you know, after discovering that the

19:40

sum of the whole was better

19:42

than the individual parts. That was

19:44

our core discovery. We really didn't

19:47

know why or whether this stretched

19:49

beyond into microbial activity, so we

19:51

spent the better part of the

19:53

last decade and a half. researching

19:56

just that. You know, we keep

19:58

looking at different, different types of

20:00

bioactivity. So antimicrobial, I mentioned, anti-inflammatory.

20:02

During COVID, we had to shut

20:05

the lab down and we didn't

20:07

know what to do. So we

20:09

thought, well, everything that we found

20:12

that lacteferent could do over the

20:14

years, we found that IDP can

20:16

do better. So there was a

20:18

lot of publications on the antiviral

20:21

activities of lacteferen. So we thought,

20:23

well, let's have a look. and

20:25

see if IDP can do better

20:27

and lo and behold it, it

20:30

does that too. Just interrupting the

20:32

show to let you know about

20:34

our patron community here and the

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been going for eight years and

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these great doctors, scientists, athletes, business

20:52

people from all around the world.

20:54

So we would love you to

20:57

come and join us. You get

20:59

a lot of exclusive member benefits

21:01

when you do, but really it's

21:03

about supporting the show and keeping

21:06

it on here. For a coffee

21:08

or two a month, that would

21:10

be fantastic if you can come

21:12

and join us. You can go

21:15

to patron. Lisatarmity.com and check it

21:17

all out. And this is one

21:19

area we still don't know the

21:21

reasons for is selective antimicrobial activity.

21:24

So you know your body has

21:26

really good bacteria all over it

21:28

and in it. We call those

21:30

commensal bacteria. They're good for you

21:33

as opposed to pathogenic bacteria which

21:35

are bad for you. Over these,

21:37

this decade and a half of

21:39

antimicrobial research, we kept finding that

21:42

the ID... P activity against the

21:44

commensals wasn't as good as the

21:46

pathogens. And so things like streptococcus

21:48

salivarius in your mouth, staphylococcus hominus

21:51

and epidermetus on your skin, lactobusili

21:53

ambiferoa bacteria in your gut, IDP

21:55

didn't do a very good job

21:57

at killing these, while it really

22:00

did a great job at inhibiting

22:02

the pathogenic bacteria. And so we

22:04

thought, well, that's interesting, but it

22:06

makes sense. Like everything goes back

22:08

to the cow, right? This system

22:11

is in developed by nature in

22:13

the mammary gland of a cow

22:15

to protect the cow from infection

22:17

and inflammation. So it makes sense

22:20

that a natural antimicrobial defense system

22:22

wouldn't develop the ability to kill

22:24

the good stuff. Yeah, why that

22:26

is? We still don't know. Wow.

22:29

It's interesting. So this is very

22:31

very powerful then for anything so

22:33

digestive related, so microbiome, because we

22:35

know this is the problem, you

22:38

know, like we talk about antibiotics,

22:40

you know, we have to take

22:42

antibiotics for some sort of disease

22:44

or something that we... absolutely need

22:47

to have but we're wiping out

22:49

our microbiome in the process for

22:51

example. So to find something that's

22:53

antimicrobial but doesn't destroy the good

22:56

guys but only destroys the bad

22:58

guys is a really a powerful

23:00

intervention really if we want to

23:02

be able to ward off things

23:05

like viruses and pathogens. gut barrier

23:07

integrity was another one of the

23:09

research papers that you've done that

23:11

showed that the the transepithhelial resistance

23:14

electrical resistance was improved so that

23:16

you got barrier is When you

23:18

get leaky gut, just for those

23:20

listening, you know, your junctions and

23:23

your gut pull apart and this

23:25

can cause major issues, just putting

23:27

it very, very, very oversimplified. And

23:29

so this improves that gut barrier

23:32

integrity. And gut barrier integrity is

23:34

just so, so I've studied this,

23:36

you know, quite a bit for,

23:38

it's just so important. because when

23:41

you have a leaky gut you

23:43

are aging faster, let's put it

23:45

that way, your organs are deteriorating

23:47

faster, you've got inflammation, you've got

23:50

your aging, you're basically aging your

23:52

organs and everything impacts the brain,

23:54

it impacts so so many things,

23:56

that's why I'm very very excited

23:59

to learn that it actually helped

24:01

with the gut barrier function because

24:03

I don't think people understand how

24:05

important that that piece of that

24:08

one sentence is. Can you explain

24:10

a little bit on that? But

24:12

we're still learning how that what

24:14

that mechanism is. We've, like you

24:17

said, we're about to publish a

24:19

paper on the the effect of

24:21

IDP treatment at the gut mucosa

24:23

level. So as you said, the

24:26

gut has a mucosa in lining

24:28

to it and those cells are

24:30

held together by connecting proteins basically.

24:32

And all the indications so far

24:35

is that when you expose those

24:37

cells to IDP, after stimulating a

24:39

breakdown in that gut junction, the

24:41

IDP can actually help start to

24:43

heal the junction. And it appears

24:46

that there may be some adhesion

24:48

proteins that get up regulated by

24:50

some or more, one or more

24:52

of the IDP proteins. So we're

24:55

still learning about that. The next

24:57

step for us there is to

24:59

try to translate that into some

25:01

human studies that makes sense. whether

25:04

they're, but you're right, that everything

25:06

starts in the gut from immunity

25:08

to inflammation. It's incredible what science

25:10

is, is discovering about the gut.

25:13

Interestingly, we've spent a lot of

25:15

time in China, a lot of

25:17

our businesses up in China. The

25:19

Chinese get this. You know, they've

25:22

talked for years about the two

25:24

brains. Yeah, yeah, yeah. The brain

25:26

up here, yeah, and the gut.

25:28

They talk about as being the

25:31

second brain of the body. And

25:33

they talk about the gut brain

25:35

axis like it's like it. Everybody

25:37

knows about it. You're like obvious.

25:40

Yeah, yeah. And so it's quite

25:42

fascinating. When I go to China

25:44

and I talk about these sorts

25:46

of things, right away the light

25:49

bulbs are on, you know, they

25:51

know that this is the way

25:53

it is. Yeah, and I'll be

25:55

interesting to see what happens in

25:58

the future with your studies in

26:00

relation to even things like mood

26:02

and, you know, mood and behavior

26:04

and depression and things like that,

26:07

whether that have an impact on

26:09

that area as well, because the

26:11

gathers very much, you know. connected

26:13

to the neurotransmitters, you know, like

26:16

what's what's happening in the guard

26:18

is going to be affecting your

26:20

brain, you know, that gut-brain access,

26:22

as you just mentioned. So it'd

26:25

be very interesting to see whether

26:27

the research goes into that direction

26:29

too and how much of an

26:31

impact that could have actually on

26:34

neurotransmitters and brains and how how,

26:36

how, there you go, another area

26:38

for to go on research. There's

26:40

no end. No, there is no

26:43

end when you start looking at

26:45

these sorts of things. Just interrupting

26:47

the show to let you know

26:49

about my longevity and anti-aging supplement

26:52

range. I'd love you to go

26:54

and check it out. Go to

26:56

my website, least sitarmity.com and hit

26:58

the shop button and you'll see

27:01

a curated range of supplements, the

27:03

latest in anti-aging, longevity, health optimization,

27:05

performance optimization. I've gone out into

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the world, interviewed the most amazing

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if you follow the show, and

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go on and got some of

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the best products that are out

27:18

there. Stuff that I give to

27:21

my family. that's what's in my

27:23

range. So go and check it

27:25

out at Lisa Tamity.com. And the

27:27

other big piece, because when we,

27:30

Peter and I came to you

27:32

and we were, you know, looking

27:34

at our formulations, we wanted to

27:36

go after immunosin essence is our...

27:39

our foundational product basically that we

27:41

were looking to to have an

27:43

impact with because immunosin essence for

27:45

those don't know that word means

27:48

basically the aging of the immune

27:50

system and that the immune system

27:52

is no longer functioning as well

27:54

when we're older and that's one

27:57

of the reasons why become so

27:59

vulnerable to all the age-related diseases,

28:01

you know, everything from cancer through

28:03

to, yeah, all sorts of viruses,

28:06

pathogens, everything. So going after that

28:08

is one of the foundational hallmarks

28:10

of aging was for us a

28:12

sort of a key factor that

28:15

we wanted to target in... what

28:17

we were doing. So we were

28:19

looking for products that were going

28:21

to, you know, downregulate some of

28:24

the inflammatory cytokines and infect the

28:26

immune system and that's how we

28:28

actually, you know, came across immune

28:30

defense protein and all the wonderful

28:33

things that it does because the

28:35

immunosinescent story is absolutely key to

28:37

us not developing things like, you

28:39

know, cancer and being falling prey.

28:42

And it just so happened that...

28:44

Everybody who listens to my show

28:46

knows that I talk at Norzingham

28:48

about mom and her story and

28:51

she's always been the impetus to

28:53

my research right and in November

28:55

and December she actually contracted a

28:57

E. coli virus. and so immediately

29:00

because we were aware of immune

29:02

defense product protein so after I

29:04

connected the dots in my brain

29:06

what was going on with her

29:09

and what was happening we put

29:11

immune defense protein in and very

29:13

very quickly within a couple of

29:15

days she started to really improve

29:18

now the interesting thing was that

29:20

and this is an end of

29:22

one not, you know, this is

29:24

not a clinical study, this is

29:27

mom. She was very, very, very,

29:29

very ill. Like, you know, we're

29:31

talking, we didn't know whether she

29:33

was going to make it. And

29:36

so it was really, really drastic.

29:38

She had this particular strain of

29:40

E. Colo was very, very, really

29:42

bad one. And her gastronterologist said

29:45

she's lucky to survive it at

29:47

her age and with her background

29:49

that she's had. As soon as

29:51

we put the immune defense... protein

29:53

in, within a few days she

29:56

started to pick up. And when

29:58

we did her next blood test,

30:00

what was interesting to me was

30:02

that her lymphocyte count had gone

30:05

up considerably. And I've been struggling

30:07

with her lymphocyte count because her

30:09

immune system is, you know, she's,

30:11

what had you say, immune impaired,

30:14

if you like, because of the

30:16

cancer background and their age and,

30:18

you know, a lot of other

30:20

comorbitities that she's had. went from

30:23

point, I think it was point

30:25

six to 1.1. I've never seen

30:27

it go over one for the

30:29

last three or four years. So

30:32

I was like, whoa, I don't

30:34

know if that was just that

30:36

or a combination of the things

30:38

that I was doing, but it

30:41

was better than it was before

30:43

the E. coli. And that was

30:45

really interesting to me. And when

30:47

I talked to one of her

30:50

longevity doctors, actually Dr. Youth, who

30:52

you've been on a call with.

30:54

She was like, well, that makes

30:56

sense, you know, because, and she

30:59

said, look, the immune defense protein,

31:01

and she studied this with us

31:03

and helped us with this, look

31:05

at this, is one of those

31:08

things that is absolutely safe for

31:10

anybody to take, and that's a

31:12

very important point to bring out

31:14

as well, because like with someone

31:17

like mom who's so fragile, there

31:19

is a lot of things that

31:21

I would like to use with

31:23

her and I can't use with

31:26

her. you know, and also with

31:28

their complicating cancer background as well.

31:30

But yeah, so that was just

31:32

a bit of an anecdote of

31:35

about her and she's on it

31:37

now every day and continues to

31:39

do well. And, you know, we're

31:41

hoping that her gut issues off

31:44

the last year, which have been

31:46

not only the E. coli, but

31:48

she had a diabetes bleeding and

31:50

nearly died a few times last

31:53

year. So I'm really hopeful that

31:55

it's going to impact, you know.

31:57

various aspects of what she's doing

31:59

so she's definitely on IDP for

32:02

life now. Well that's that's great

32:04

to you Lisa like you said

32:06

it's an end of one so

32:08

I mean It's hard to straighten

32:11

to light that, but yeah. Exactly,

32:13

that, to IDP, but you're absolutely

32:15

right, IDP is completely safe to

32:17

take. It's a naturally occurring sweet

32:20

of milk proteins, milkway proteins, and

32:22

in fact, it's even safe to

32:24

take for people who have natural

32:26

milk allergies because it's missing the

32:28

allergenic milk proteins. That has no

32:31

lactose in it. So no lactose

32:33

in it. A really, really important

32:35

point because there will be people

32:37

listening to this going, is there

32:40

lactose in it and am I

32:42

going to get milk allergy from

32:44

this? So absolutely no lactose in

32:46

it. No lactose in it. The

32:49

sugar is gone. The milk sugar

32:51

is gone. And like I said,

32:53

IDPs extracted from the way. And

32:55

so there is minimal levels of

32:58

those things left. Right, so no

33:00

lactose and then only minimal of

33:02

these other, I can't even say

33:04

those two words yet. Alpha lack

33:07

and beta lack, those are the

33:09

ways. Alpha lack and beta lack,

33:11

okay, I can probably cope with

33:13

that. So, so, so very few

33:16

people could have a still an

33:18

immune response to that, perhaps. Well,

33:20

it's possibly, I mean. I

33:23

met somebody the other day

33:25

that was allergic to pepper,

33:27

black pepper for them the

33:29

sake. So I mean, anything

33:31

is possible. Yeah, we can

33:33

have allergies to anything. But

33:35

generally speaking, those who are

33:37

lactose intolerant, which is quite

33:39

a common thing, won't have

33:41

a problem with us. That's

33:43

important. Okay, so if we

33:45

go back to the immune

33:47

story, interlocking 6 and T&F

33:49

Alpha are two things that

33:51

were very clearly on our

33:53

radar that we wanted to

33:55

reduce in our... people that

33:57

are taking what their formulation

33:59

because those two are very

34:01

much known as being the

34:03

aging cytokines if you like

34:06

the cytokines that go up.

34:08

like with age, which have

34:10

a very big, you know,

34:12

detrimental effect on low-grade sort

34:14

of chronic information in the

34:16

body, which is adding to,

34:18

well, many, many problems in

34:20

the body, aging, it's aging

34:22

you, it impacts your NAD

34:24

levels, for example, which I'm

34:26

deep in the research on

34:28

NAD at the moment. So

34:30

for us, that was a

34:32

connecting story to... N-A-D, which

34:34

was interesting as well, but

34:36

I won't get off topic.

34:38

So Interleaken 6 and T-N-F-Alfa,

34:40

tell us about those and

34:42

how it impacts those immune

34:44

defense protein. Right, so in

34:46

the early days, like I

34:48

said, we were looking around

34:50

for anything that Lactifan could

34:53

do, we thought IDP could

34:55

do better, and so we

34:57

jumped into the anti-inflammatory space,

34:59

and we started out with

35:01

some rat neutrophil studies. down

35:03

in Wellington at Trinity Bioactives

35:05

just looking at in a

35:07

in a cell line when

35:09

you stimulate inflammation in rat

35:11

neutrophils and then treat them

35:13

with IDP. Did you decrease

35:15

or increase or not change

35:17

at all the levels of

35:19

inflammatory cytokines being produced and

35:21

we looked at IL6 and

35:23

T&F alpha specifically for that

35:25

study and we found that

35:27

in fact it did do

35:29

that. Interestingly, lactiferin at high

35:31

concentrations actually stimulated the production

35:33

of T&F alphan I-L-6. That

35:35

surprised us a little bit

35:37

till the immunology people told

35:40

us, well, that's to be

35:42

expected, lactiferin's role in the

35:44

immune defense system is to

35:46

actually kickstart your immune defenses,

35:48

which so inflammation is given

35:50

a bad rap, it's the

35:52

overremplation, it's the problem. That

35:54

actually, let's pause there and

35:56

actually, you know, explain that

35:58

a little bit because yeah,

36:00

IL6 and T&F alpha and

36:02

other side of kinds, we

36:04

want in that initial phase

36:06

of the response to APA.

36:08

or to a virus or

36:10

whatever the case may be.

36:12

It's the ongoing chronic, low-grade

36:14

inflammatory upregulation of these cytokines.

36:16

That's the problem. So yeah,

36:18

that would explain why yes,

36:20

we wanted in the first

36:22

instance, we don't want it

36:24

for going on for a

36:27

month or years afterwards. Yeah.

36:29

So that was a little

36:31

surprising where we saw high

36:33

doses of lactiferous stimulated production

36:35

had a pro-inflammatory effect. Whereas

36:37

equivalent doses of IDP with

36:39

all of those other immune

36:41

defense proteins in there decreased.

36:43

Oh wow, okay. So you're

36:45

looking at actually, you know,

36:47

the theory was, well, it's

36:49

a natural defense system, therefore

36:51

it probably has synergistic proteins

36:53

to regulate as well as,

36:55

and to this day, we

36:57

don't understand which ones those

36:59

are and how that's working,

37:01

but it's consistent, it's repeatable.

37:03

So we decided to jump

37:05

into a clinical study to

37:07

look at IDP supplementation. We

37:09

did a double-blunded placebo-controlled study

37:12

in California, looking at patients

37:14

that have predisposition to inflammation.

37:16

And we looked at four

37:18

inflammatory markers in the blood,

37:20

C-reactive protein, L-D-L, and I-L-6-10-T-10-F

37:22

alpha. In all instances, all

37:24

four markers that we looked

37:26

at, the IDP had a

37:28

suppressive effect versus the placebo.

37:30

So we actually had IDP

37:32

reduced the number of subjects

37:34

showing an increase in those

37:36

markers and IDP reduced the

37:38

percentage increase in the key

37:40

markers over the placebo effect.

37:42

And so there's definitely something

37:44

going on that it's probably

37:46

happening at the gut level

37:48

again. because you're ingesting these

37:50

things in that particular study

37:52

we put all these the

37:54

placebo and the IDP into

37:56

capsules so it bypassed any

37:59

effect they were in the

38:01

mouth or the throat. So

38:03

definitely all gut level things.

38:05

So yeah, it's, it's, again, these,

38:07

I come back to the cow,

38:09

you'll hear me say that

38:11

story a lot. These things

38:13

were designed to do certain

38:15

functions in the animal.

38:18

Synogistically. The inside

38:20

of the mammary gland of

38:22

a cow has secretory. milk

38:25

secretion cells, secretory epithelial tissue.

38:27

Those tissues are held together

38:29

by type junctions in just

38:31

the same manner as your

38:33

gut mucos is held together.

38:35

So when a cow gets

38:37

mastitis, they get a bacterial

38:39

infection that forms a biofilm

38:41

on the milk secretory tissue. If

38:44

that inflammation takes and the

38:46

inflammation grows, the tight junction

38:48

starts to break down inside

38:51

the memory gland and you get

38:53

mastitis. And so... Again, it's not

38:55

surprising. What we're trying to do

38:57

with IDP in human health is

38:59

to use it in the exact same way

39:01

that the cow uses it. The exact

39:03

same way it's been designed by nature

39:05

to be used. And I guess that's

39:08

what sets IDP apart from other

39:10

natural health product ingredients

39:12

maybe. Yep. Yep. Yep. There's lots

39:15

of botanical extracts that do

39:17

these things too, but you know, a plant

39:19

isn't worried about getting mastitis.

39:21

Just to pause on that

39:23

point, you know, the more I

39:26

study things, the more I'm interested

39:28

in the complexes of things,

39:31

you know, like, for example,

39:33

I've been looking into

39:35

spermidine, which is another

39:38

supplement that I'm, you

39:40

know, very enthusiastic about.

39:43

Upregulates autophagee has a major

39:45

impacts on the body in good

39:47

positive ways. But when we looked

39:49

at the synthetic spermidine versus the

39:51

one that comes from wheat germ

39:54

or chlorella is another and it's

39:56

in the complex, you know, it's

39:58

in the complex of spermene. future

40:00

scene, all these horrible sounding

40:03

names, pemidine. When it's

40:05

in that complex I think

40:07

it's much more effective than

40:09

when you take out one single

40:11

part of it and synthesize it

40:13

and you know and I wonder

40:16

I don't know if that's the

40:18

case in everything but I think

40:20

you know I wonder that like

40:22

nature is amazing and it's a

40:24

it's a it's evolution and how

40:26

it's bought things about for and

40:29

over millennia and billions of years

40:31

it's probably brighter than we are

40:33

you know so there might be

40:35

reasons why certain things are grouped

40:37

together and it's it's an interesting

40:40

area to think about at least

40:42

you know like does you know

40:44

when you when you have something

40:46

that you've pulled out versus And

40:48

I think there are two sides

40:51

to that and each molecule will

40:53

be different that you're looking

40:55

at, but sometimes the extract,

40:58

sometimes the combination, but

41:00

just that whole complex

41:02

can sometimes be an

41:04

interesting thing to think about.

41:06

Yeah, well nature is a

41:08

system, you're absolutely right, and

41:10

nature systems to develop over

41:12

a long period of time

41:14

to do things together. It's

41:16

like a team. And you know,

41:19

you might be able to see

41:21

Lacta Faren as the full back

41:23

on a team, so a very

41:25

important player. But there's a bunch

41:27

of other ones there that are

41:29

needed to win the game. So

41:31

I think, I think you're right.

41:33

You know, there probably are

41:36

things you can extract and

41:38

purify from nature that are effective.

41:40

I mean, we know that's good.

41:43

But quite often. the sum of

41:45

the whole is better than

41:47

the individual parts. And I get

41:49

asked a lot, can I DP do this

41:51

or can I DP do that? My first,

41:53

before I even answer that question, I

41:55

have to go away and think, is

41:58

there a plausible reason? and

42:00

why IDP would do that in the

42:02

cow. And if there isn't, I

42:04

come back to, well, probably not.

42:06

It's probably not a

42:09

mechanism involved that would

42:11

make that work. Wow. And on that

42:13

point, I'm just thinking about,

42:15

you know, ladies who are

42:18

breastfeeding and getting problems with

42:20

my status and that type

42:22

of thing. It doesn't work

42:25

topically as well. You know really

42:27

they feel Christian for you to

42:29

go away and think about it.

42:31

Well, I can answer that very

42:33

quickly because we want one of

42:35

our key areas of contact over the

42:38

years has been to try to

42:40

use IDP based formulations

42:42

as natural treatments for

42:44

anestitis. Wow. Okay. So, so when you

42:46

say topically, like I said before,

42:48

the inside of the cow's mammary

42:51

gland is. secretory epithelial tissue.

42:53

So it's like the skin on

42:55

your body, but without the tough

42:58

epidermis on over top of it.

43:00

So it's a very vulnerable skin.

43:02

It's an internal skin. But these

43:05

milk proteins are actually

43:07

acting inside the cow in

43:09

a topical way. Yes. Now the

43:11

difference between a cow's mammary gland

43:13

and a human breast, of course,

43:15

is that the cow's mammary gland

43:17

has a cistern. So it has

43:19

a... cavity inside the mammary

43:21

gland of a cow that

43:23

holds a portion of the

43:25

milk till the cows milked

43:27

again. Humans don't have

43:29

that. So all the milk

43:31

ducks end externally in a

43:33

human. So you can't actually

43:36

infuse IDP into a

43:38

mammary gland of that anatomy.

43:40

Right. Okay. But you can

43:42

certainly use it topically. I mean,

43:45

we use it for in a

43:47

skin care range for... alleviating

43:50

acne. So, you know,

43:52

the IDP kills the

43:55

pathogenic organisms associated with

43:57

acne but doesn't affect...

44:00

commensals like I said on the

44:02

skin. Like it does with a microbiome.

44:04

Wow. And it reduces redness and irritation

44:07

from the acne lesions so we've got

44:09

clinical data to support that as

44:11

well. Wow okay that's that's really

44:13

interesting because I mean information on

44:15

the inside information on the

44:18

outside doesn't probably make a difference

44:20

where you know the way it's being

44:22

used. Okay so so so We know it

44:24

does gut barrier, we know it

44:26

supports the immune system with

44:28

the IL6 and the T&F

44:31

alpha, we know it kills the

44:33

bad bacteria, doesn't call the

44:35

good bacteria. What else does

44:37

it do? Is it what,

44:39

you know, what other major sort

44:42

of things? Oh, I did want

44:44

to ask you about the latest

44:46

research on on South COVID-2 and

44:48

COVID. Are we allowed to talk

44:51

about that? A little bit, a

44:53

little bit. You're just about to

44:55

publish that, Lisa, so I have

44:57

to be a little bit careful.

45:00

Yeah, no, don't get yourself in

45:02

trouble. But yeah, so like I

45:04

said, we're up front, when

45:06

COVID hit us in 2020, we

45:08

were kind of locked out in

45:10

a lab, we didn't know what to

45:12

do. anti-barrel everything

45:15

was all over the news

45:17

and so we thought well

45:19

Lactifern has been published with

45:21

anti-viral effects so let's see

45:23

what happens and so we

45:25

sent some IDP samples with

45:27

some purified Lactiferna

45:30

off to a lab in the

45:32

US to look at does is

45:34

there any hint of anti-baro activity

45:37

with IDP versus Lactifern and so

45:39

this lab it was all in vitro

45:41

study so it's... lab dish based stuff

45:44

where they take viruses they have some

45:46

human cell lines that they grow up

45:48

and they expose the human cell lines

45:51

to the products and and the

45:53

viruses and see if the viruses

45:55

can actually enter the cells which

45:57

is how viruses affect you and work

45:59

and so So we looked at

46:01

HSV1, Influenza A and B,

46:03

Hadino virus, and they also,

46:06

quite quickly, this lab was

46:08

pretty onto it. They had,

46:10

they didn't have SARS COVID-2,

46:13

but they had a, a, what

46:15

do they call it, a mimic that

46:17

does the same job, I guess.

46:19

And so in all five cases,

46:21

IDP prevented these

46:24

viruses from entering the

46:26

human cells. on par or

46:28

better than the lactiferin. And

46:30

so in one of those

46:33

cases, HSV1, they were equal.

46:35

In all other cases, IDP

46:38

did a better job. So

46:40

that was an interesting result

46:42

in itself, telling us

46:45

that it was probably

46:47

the lactiferin in the

46:49

IDP for HSV1 that was

46:52

doing the antiviral job.

46:54

But for the other four... I

46:56

just think, yep, yep, yep. And

46:58

for influenza A and B and

47:01

adenovirus and the SARS mimic, there's

47:03

something else in the IDP that

47:05

made it even better. Whatever that

47:07

might be, there's probably another binding

47:10

protein in there that were two

47:12

that do that job. And so

47:14

what we did after that work

47:16

is we decided to see if

47:19

we could actually translate that

47:21

to some human functionality. Just

47:24

blocking spike spike spike probably

47:27

didn't indicate that it was going

47:29

to be an antiviral ingredient. I

47:31

mean, that's just a big ask.

47:33

But what one of the things I've

47:35

thought about over the years is,

47:37

you know, you often have the

47:39

natural health products sitting on one

47:41

into the spectrum and the pharmaceutical

47:43

products sitting on the other. They

47:46

fight each other, the companies, one

47:48

or the other. But well, hang

47:50

on, you know, nature doesn't work that

47:52

way. Antivotics are really effective

47:55

and really good. Antivirals vaccinations

47:57

are important, vastly important to

47:59

do. What if we did some

48:01

type of combination therapy on the on

48:04

the two things? So, you know,

48:06

actually using high D.P. supplementation, for

48:08

example, in combination with vaccination and

48:10

see what happens with that. And

48:12

so that's that's about as far

48:14

as I can go with that.

48:16

Like I said, we did just

48:18

finished a clinical study last year,

48:20

got some amazing results. We're about to

48:22

publish those this year, but watch

48:24

this space. It's pretty exciting. Because

48:27

that could, yeah, explode in

48:29

a good way. But you have

48:31

got in the past one with

48:33

the influenza vaccine. We can

48:36

talk about that one. That's

48:38

the one we're about to publish.

48:40

Oh, okay. So that, okay. Yeah, yeah.

48:43

Because this, this, this is really

48:45

important as you, as we get

48:47

older, we don't actually, older

48:50

adults don't, you know, we

48:52

know that they don't respond to vaccines

48:54

very well because they can't produce

48:56

the antibody. So that's the actual

48:58

thing that we're getting at here that

49:00

improve that. Okay, so watch the space

49:03

for more information on that publication. So

49:05

do let me know when that comes

49:07

out. Perhaps we'll get back on to see

49:09

a little bit deeper what you're allowed to

49:11

talk about then. Hey everyone, just

49:14

interrupting the show really briefly to

49:16

let you know about some exciting

49:18

news. We have just launched our

49:20

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Lisaaitamity.com and the link will also

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be the show notes below now

50:36

back to the show. So is there

50:38

any other things that we haven't

50:41

covered off that you think we

50:43

should be sharing about IDP and

50:45

its wonders any other areas in

50:47

health so you know besides the

50:50

microbiome the immune system? Those alone

50:52

are a pretty big pretty big

50:54

deal. Yeah I mean those those are

50:56

definitely the focus of our

50:59

business now we continue to

51:01

learn about mechanisms. We think

51:03

it's quite important. that whenever

51:05

we find IDP can have

51:07

some sort of effect that there's

51:09

a plausible reason why it's having

51:12

that effect. And, you know, our

51:14

research now is focused on three

51:16

main areas, immune health,

51:18

digestive health, and microbiome

51:21

support. So definitely we've covered those

51:23

pretty thoroughly, I think. Yeah. I

51:25

mean, I can talk about this

51:27

all day, but yeah. But I

51:29

think we have, you know, I

51:31

could too, actually. Just interrupting the show

51:34

to let you know about my longevity

51:36

and anti-aging supplement range. I'd love you

51:38

to go and check it out. Go

51:40

to my website, least sitarmity.com and hit

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51:45

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best products that are out. there. Stuff that

52:00

I give to my family, that's what's

52:03

in my range. So go and check

52:05

it out at Lisa Tarmity.com. But

52:07

you know from the, can

52:09

you just touch briefly on the

52:11

Lactoporoxidase because that is another

52:14

one of the major sort

52:16

of players in this. What

52:18

is Lactoporoxidase per se? What

52:20

is that part of that story?

52:22

Yeah, yeah, Lactoporoxylase

52:25

is the second most abundant.

52:27

milk protein in IDP. It has

52:29

a minimum level of 18% as opposed

52:31

to the lactifamel, which

52:33

is a minimum 40%. And

52:36

so the lactoporoxidase is an

52:38

important molecule for an antimicrobial

52:41

point of view. So lactoporoxidase

52:43

is an enzyme. So like

52:46

I said before, enzymes catalyze

52:48

the reaction of two substrates

52:50

into a product. In the

52:53

case of lactoporoxidase, lactoporoxidase. makes

52:55

a peroxide react with

52:58

a halide, which is a

53:00

chemical compound like

53:02

sodium thiocyanate or

53:04

potassium iodide. The resulting

53:07

product of that

53:09

reaction is a

53:11

short half-life, highly

53:13

inhibitory molecule. And

53:15

so lactoporoxidase is a

53:18

very important natural

53:20

defense protein for...

53:22

frontline defense for killing

53:25

pathogenic organisms or inhibiting

53:27

pathogenic organisms. You have

53:29

lacked a peroxidase in

53:31

your tears. It's very abundant

53:33

in your saliva. And like

53:35

I said, it's the second

53:38

most abundant protein in the

53:40

bioactive part of the way. And so

53:42

that's going to be mainly on that antimicrobial

53:45

side of the story. Mainly so,

53:47

but also it, like I said,

53:50

one of the substrates is peroxide.

53:52

So it actually... contributes to the

53:54

antioxidant effect too because it mobs

53:56

of the free radio. Okay, so it's a

53:59

free radicals. Yeah. So is it sort

54:01

of part of that sort of

54:03

glutathion, you know, antioxidant or? Well,

54:05

it's more the peroxide and the superoxide.

54:08

So, you know, peroxide can

54:10

be quite irritating, but again,

54:12

it's quite an important molecule

54:14

in the body's immune defense

54:16

system. And so we were

54:18

pretty sure that it's primary the

54:21

LP that's responsible for reducing the

54:23

redness and irritation, say when you

54:25

put IDP base streams on your

54:27

skin. And yeah because peroxide

54:30

you know like in it's

54:32

like a disinfectant as we

54:34

know peroxide is on the

54:36

outside actually on the inside

54:38

that the body produces but

54:40

then we have to get

54:42

it rid of it and

54:44

break it down so this would

54:47

help with that process at

54:49

all like you know breaking it

54:51

down so I'm always looking

54:53

out for things that stop my

54:55

hair growing gray would that

54:57

help? I've asked you some random

55:00

questions today, haven't I? But anything

55:02

that breaks down peroxide is probably

55:04

going to help. So I might

55:06

put that in as an extra.

55:08

I might have thought about that

55:11

application about growing here, not gray

55:13

here. Well, I can tell you,

55:15

if you can solve people's here

55:17

going grey, that would be a

55:19

really big market. Who knows? I'm

55:21

giving you a whole lot of

55:23

areas to go and study for

55:25

the next 20 years I think.

55:28

Oh Dr Rod, you've been wonderful

55:30

today. I'd like to thank you

55:32

so much for taking the time to do

55:34

a really deep dive into this

55:36

very exciting immune defense protein.

55:38

We're really excited to work with

55:40

you and your company hopefully soon

55:43

to get our first formulations out

55:45

the door and we're excited to

55:47

see where this goes this research

55:49

and would really encourage people. to

55:51

stay tuned for more information on

55:54

this and we'll be hopefully having

55:56

our formulations soon. If you wanted

55:58

to get your hands... some now.

56:00

I've actually got it now in my

56:02

shop. One of the, they've kindly set

56:05

me up. So before we get

56:07

our formulations out, which may be a

56:09

month or three, you can still get that.

56:11

So I'll put links down below

56:13

to doing that if you're interested.

56:15

But thank you so much. Dr.

56:17

Rod, you've been fabulous. Any last

56:19

words before we wrap up today?

56:22

Not really Lisa, just thanks so

56:24

much for having me on the

56:26

show and to your listeners, thanks

56:28

for listening. We love talking about

56:30

the wonders of milk and the wonders

56:32

of nature, so it's just been a

56:34

real pleasure to talk to you today.

56:36

Oh, it's been absolutely fabulous and

56:39

I've learned a lot about cows,

56:41

I can tell you that much. Thanks,

56:43

Dr. Odd. That's

56:45

it this week for pushing the

56:47

limits. Be sure to rate, review

56:50

and share with your friends.

56:52

Head over and visit

56:54

Lisa and her team

56:56

at leasitomity.com.