0:01

You're

0:01

listening to be human upgrade with Dave, asprey

0:04

formerly.

0:08

Bulletproof radio.

0:11

You're

0:11

listening to the human upgrade with Dave

0:14

asprey. Then.

0:57

Case you haven't noticed, I am one

0:59

of those guys that, as pro nutrition

1:02

pro lifestyle, I'm also pro

1:04

forma in other words, you

1:06

look at risk reward for everything you can. Do

1:08

and either side was gonna work best for you,

1:11

and think there's some interesting knowledge to

1:13

be had today. Robert,

1:15

welcome to the shop. Hey

1:17

thanks for inviting me pieces are.

1:20

you feeling depressed about the state of obesity

1:23

in the world now having studied as for

1:25

a few decades

1:28

While. "We a certainly challenge as we

1:30

know I will add those that

1:32

the Colvin nineteen pandemic

1:34

off, the first time in my career

1:37

or has said an acute

1:39

power response. To it in other words

1:42

people are aware that obesity not

1:44

only affects long term problems like developing

1:46

diabetes heart disease, said

1:49

he liver high cholesterol so forth

1:51

but now for the first time it's a

1:53

risk factor for in immediate contagious

1:56

disease which you really never seen before

1:59

so i think it's shuttle It's on the importance

2:01

of obesity more than anything I've seen

2:03

in my forty years of our career with.

2:06

haven't overweight people always been

2:08

as statistically higher risk of dying

2:10

from all infections bacterial viral

2:12

everything else is it does give them poor immune

2:15

function in higher inflammation Yeah.

2:17

Let's say here in In is an interesting

2:19

from a stork: A point of view is a metropolitan

2:22

life insurance or group or

2:24

in the nineteen thirties, forties and fifties

2:27

that first. Brought light to the fact

2:29

that individuals who are overweight has

2:31

higher mortality rate, Greg, to the one is

2:33

or people rightfully of not, while many how

2:35

much premiums to the. Church and people on

2:38

the found very early in the West century

2:40

that individuals who are overweight died

2:43

earlier we've known this for long

2:45

time but, the arm

2:47

of. "The cause of death for most people

2:50

would obesity, the our interests are

2:52

dying, certain individuals who do not

2:54

yet will be six is room for the ongoing

2:56

medical problem", said Develops. Like heart

2:58

disease hypertension stroke,

3:01

diabetes one of the highest in

3:04

such diseases were come in and

3:06

you know in the nineteen hundreds but they

3:08

really were dying most the of the underlying

3:10

medical problems and then she got pneumonia and

3:12

you're more likely to die

3:14

This may be a bit of an inflammatory

3:16

and question. Right? Given.

3:19

That when people die with one medical

3:21

condition, we give them but if up

3:23

five medical conditions, but they have one medical

3:25

condition, we always pick one and it seems

3:27

to. Be the most popular one isn't

3:29

obesity actually the cause of death

3:32

for people who are dying

3:34

of heart disease and or

3:36

even cancer because the risk it is all it

3:38

is. Is foundational root cause or

3:41

is it just an associate thing that wasn't related,

3:43

elected the fat come first of this disease?

3:51

The more than twenty years I've been using new

3:53

tropics problem is that everyone's

3:55

brain chemistry is unique

3:57

and it's hard to know exactly which new tropics.

4:00

Are going to work best for your brain cuz

4:02

it's not the same as Persians. Next year. I

4:04

spent years perfecting my snack, but

4:07

now my friends at bioptimizers have

4:09

made a new company that offers 100%

4:11

per customized nootropics

4:13

tax to take out all the work that I i had

4:16

to do to build a sack. He

4:18

fill out an intake form at newtopia.com

4:20

in o a calm

4:23

and then they customize nine

4:25

of their core Blends based on the goals.

4:27

You have and based on your own brain chemistry help

4:30

you get to your best goals after every

4:32

day when you take opiates with

4:36

an app that allows i to give feedback. So when

4:38

you get your blend, it'll be tuned for

4:40

how you feel. Go to newtopia.com

4:43

Dave, and you go Dave, 10, I'll give you

4:45

10% off your first order This is

4:47

a high-end amazing way to get

4:49

your brain right where you want it really in

4:51

00 t, o p. I i a calm

4:54

day if you spell dividend. Foundational

4:59

route. or is it just an associate

5:01

thing that wasn't related elected the fat come first

5:03

of the disease comforts yeah,

5:06

yeah it's great questions ah

5:08

but you know the cause of death from the coroner's

5:11

report? is always what is

5:13

it that cause immediate death Heart.

5:15

Attack stroke you,

5:18

know aneurism to heart complications

5:20

with diabetes rarely does that

5:22

list obesity with Dave you're absolutely

5:24

correct obesity is the

5:26

seating ground for all these

5:28

ongoing chronic problems. But

5:30

it's rarely listed I'm on

5:33

death certificate almost the and mom or think Dave

5:35

is that it is uncommonly listed even

5:38

in your medical record when you go to your.

5:40

Doctor, for Friday reasons,

5:42

they don't make diagnosis, data one of

5:44

the patient, the doctor not thinking

5:46

about obesity, which is the fair

5:48

I and is causing, and for

5:50

it causes. Use as of a many

5:52

medical problems at people up in the country.

5:55

so my idea of it's something we

5:57

may have problem with coroner reporting

6:00

Our corners are saying, oh, what's that the latest

6:02

thing that got them at, I look at

6:05

mitochondrial function in obesity as going

6:07

together in the seem to be? Some

6:10

of the major root causes of pretty

6:12

much everything that kills you if it's not a truck hitting

6:14

you and even then. An obese

6:16

person isn't going to survive as well as someone

6:19

who has more lean mass and was body fat.

6:21

Right?

6:23

Yeah. Well, they certainly have a lot energy reserves,

6:25

but unfortunately what we've learned in passed

6:28

out of fifty years or so, or the Western

6:30

ghats, is that obesity has had

6:32

always. Been thought of as excess body

6:34

fat didn't cause any problems but

6:37

if you got sick enough regarding overweight

6:39

enough than twelve guy beasts we

6:41

now know for the past decade. Said obesity

6:44

in itself is disease that you're alluding

6:46

to the earlier. Okay.

6:51

They even though you said he obesity one

6:53

of the things I've come across just in my

6:55

own are losing up the hundred pounds I've

6:57

lost or is that?

7:00

You look in Hollywood easy, these mean

7:02

they read shredded men and women

7:04

who are down at the of five, six percent

7:06

body fat probably does for centers more for men,

7:09

but women under ten.

7:11

There must be some lower lower.

7:13

limit to how much fat you can lose

7:16

and still remain healthy do you have a perspective

7:18

on that before get into that the mr weight loss

7:21

Well. Elite, your Fc right and your talk

7:23

little bit more about our earlier about

7:25

Arm, you know what we're engineer

7:27

really well, for instance, neared and decide. To

7:29

do and defend our self assign in your

7:32

here and your conversational bit earlier arm,

7:34

we are designed or

7:37

engineer to have certain amount of body fat.

7:39

Or optimal health is probably most parents

7:41

and women. if woman

7:43

loosest much body fallacy to

7:45

marathon runner raged is very

7:47

lean or she has disease like anorexia

7:49

nervosa were body fat

7:51

drops below threshold for

7:53

health you start shipping ramifications

7:56

in for health show started having

7:58

memory as to stop me Trading. Or

8:00

bones will become sin infrared, all developing

8:03

osteoporosis arm

8:05

should become weaker in her muscles,

8:07

or inch will be able to reproduce and,

8:09

and as really gets biologically most fundamental.

8:12

A hard thing as a gift out of body fat

8:14

reproduced him to mistreat normally and

8:16

any fertility, so let's pray the

8:18

best example that door as lower

8:21

limit of. "An of body fat as an individual

8:23

have in minute's little harder

8:25

to, you know, mom on, make

8:27

diagnosis to the seal, have the same issues

8:30

that woman has. Where it becomes or parents?

8:33

Game. And, we probably don't have

8:36

an interest certain hardcore threshold

8:38

because it's different for different people but I just

8:40

want people listening and who are in that

8:43

into fitness competitor. Industry in there's

8:45

a bunch people like I wasn't shouts who

8:47

is possible to get to mean

8:49

and it's hard to say to Lean for

8:51

too long without a lot of biological. Stress

8:54

so you can look like Wolverine, but Wolverine

8:56

was taking tire addicts to remove

8:59

extra water from his Issues for that shirt off

9:01

shot where he had no slices of tank in half

9:03

with his fingernails. I'm so I

9:05

just want to run listening, pay

9:07

attention to that side of obesity But

9:09

since you studied, what happened to me, it was happening

9:11

to a large percentage of people

9:14

in the world. Now, is

9:16

we're getting fat and we're looking for

9:18

all these different reasons. And

9:20

we're going to get into the semaglutide which

9:22

I'm really excited about it. But if

9:24

you had to say the number one

9:26

thing of what might be list of five things

9:28

you think contribute. But the top of the

9:30

list that you think given

9:32

all of your knowledge, even if you don't have a study about it,

9:34

where would you point your finger first engineer

9:39

lights down in Western culture? Our

9:42

genetics, as you can imagine, if not

9:44

changed over the past one hundred years,

9:47

but yet the prevalence of obesity

9:49

at least the United States has gone from

9:51

I'll be the high twain. Twenty percent,

9:53

or so, up to forty two percent, so

9:55

it's doubles are in a fairly short

9:58

period of time and obese. Now.

10:00

The most common non communicable disease

10:03

worldwide, and I think we could think

10:05

of interflora things are environments, writers,

10:07

different exposures that we have certainly

10:10

food Cisco activity I'd

10:12

say change in. Our food supply I'd

10:14

say there probably is the is generating

10:17

increased risk of obesity among vulnerable

10:19

individuals are likely to take it

10:22

to be just come to that and him. I'm

10:24

overweight. They've got a that it's

10:26

one of those multi very it answers were

10:28

was lifestyle food changes but we

10:30

don't know which food changes man I'd I would have

10:33

some some. ideas on that

10:35

we could probably spend the next couple hours talking

10:37

about ah and i'd

10:39

love to learn from your perspective

10:42

on those but what i really want to talk about

10:44

is this new england

10:47

journal of medicine article they came

10:49

out not too long ago about once a week

10:51

with some ugly tied in people

10:53

who were obese or overweight

10:56

can you tell me about the study and

10:58

what smuggler tide is and or

11:00

what you found Absolutely. So

11:02

one the things we've learned over the past few

11:04

decades arm is that

11:07

obesity as disease is characterized

11:09

by we call I kept take this regulation

11:12

of fancy word by. Saying that individuals

11:14

who are vulnerable the gaining weight

11:16

do not regulate their cap, it's I'd normally

11:19

if you're not prone to developing obesity

11:22

if you overeat one day you're likely

11:24

be. A little less humphrey the next day you'll

11:26

feel full sooners won't be as hungry

11:29

and u n you buy you a pretty much regulate

11:31

normally individuals, who are

11:33

predisposed. To becoming overweight don't

11:36

get that sense of I'm full, I

11:38

need to stop eating arm I'm not

11:40

hungry anymore and by losing

11:43

those internal signals big

11:45

they often tend to eat. More than your body

11:47

needs of deaths the genesis of that.

11:50

we also have learned that door of hormones

11:52

nobody that govern whether

11:55

you're hungry or for signals the

11:57

come from the got go up to the praying in

11:59

the us with actually How many you and my hungry

12:01

or my for my thinking about food am

12:03

having cravings those are all biological

12:06

signals one? of those of

12:08

we get is a hormone the constant got and

12:11

is called c o p one kazuko gone

12:13

like peptide voice so

12:15

There. Are several years ago

12:18

if I decorate a more golf, the pharmaceutical

12:20

industry and picking up on the as said,

12:22

"If we can mimic this job,

12:24

the one hormone that normally makes" us

12:26

feel full and reduce our current

12:28

hunger, maybe we can give it back

12:31

to people who do cook don't have to

12:33

don't get that signal and help them

12:35

with normal" appetite hog regulation

12:37

or signal that, is what Makayla

12:40

tighter some aclu tight is if they

12:42

mimic it mimics are

12:44

naturally occurring hormone called C

12:46

& O one too many give. It back to a person

12:48

and pharmacologic dose is so high doses

12:51

but it mimics what we normally have, it

12:54

both men's or highlights

12:56

this feeling of you know. What I'm really not

12:58

as hungry as I was

13:00

before must ah more

13:03

full than it was before so

13:05

don't need as much. food and

13:07

is actually the change and appetite

13:09

the cause to the weight loss that we see with

13:11

this kind of a draw

13:14

So people want to eat less am.

13:17

what i found when was working on

13:19

losing that One hundred pounds is

13:22

that I was going to the gym an hour and a half day,

13:24

six days week, and I went on a

13:26

low calorie, low fat diet

13:28

and I didn't lose weight by was hungry

13:31

all that time. But

13:33

the fact that was definitely.

13:36

exercising that much and really

13:38

not eating as much as I would

13:40

have liked. They didn't make a difference.

13:42

What happens when people

13:45

don't have a hunger signal?

13:47

They. Are they gonna lose muscle, are

13:49

they going to lose fat because it seems

13:51

like if you're not getting as much energy as the

13:53

body wants because you that you're not? hungry or you can

13:55

get cold, are you gonna get siren conditions,

13:57

are you and he gets up on or immunity?

14:00

It. Seemed like inducing stress in the body to

14:02

have less energy than it was here,

14:05

for the all the V is a goal of our

14:07

of the what we try. Doing

14:09

we help people lose weight or manage

14:11

their weight or for weight, is to

14:13

lot of lifestyle counseling for to store clerk

14:16

in say can happen follow A. Healthy balanced

14:18

diet puppy more plant based reduce

14:20

simple sugars and so, forth affected

14:23

you said you started feeling

14:25

hungry as you lose weight is very,

14:27

very common occurrence. In individuals

14:30

who are trying to lose weight and that is how we

14:32

are genetically engineered, we

14:34

are genetically engineered not to lose weight actually

14:36

to meet senior weight that are you. Maintain

14:39

species and as you start

14:41

losing weight, you get hungry or, or

14:43

in large part, what makes

14:45

wait this long term weight maintenance so

14:48

challenging because you can't fight

14:50

on? Going hunger of actually you give in,

14:52

to it now when you do lose where

14:54

you're from what happens, to the body in

14:56

general depending upon what kind of died.

14:58

During your exercise roughly about

15:01

two thirds of what you'll lose his

15:03

body fat and roughly about

15:05

one third or one forth between. which

15:08

is muscle now few he had lot

15:10

of intensive physical activity prickly resistance

15:12

training you can you can you

15:14

can maintain much more of the lean

15:16

body mass from off the ledge you lose weight but

15:19

in general someone's going to doctor

15:21

are going to curse weight loss program

15:23

about two thirds of your weight loss going to be forgotten

15:26

about one third or one fourth is awesome

15:30

Okay so there is gonna be some weight

15:32

loss unless you're training died.

15:35

as i have just over a question

15:37

some if you just don't wanna eat what happens

15:39

and lot of the work i've done with intermittent fasting

15:41

you get to that point where you're just The

15:43

not hungry you could eat, but you don't need to eat.

15:46

The and lifestyle things

15:48

like that, but then when you do eat what you eat

15:51

still matters. I'm

15:53

a.

15:55

Any any comments on that some

15:57

a good idea if it's? The acting

15:59

on job. One so people are

16:01

losing weight does. that work

16:03

well with fasting does it work better with as

16:05

things that make fasting easier or as it's

16:07

something that you just too independent

16:13

Then. Years ago, I

16:15

decided to build a community where

16:17

I could spend some quality time with people who

16:20

are like me, people cared about taking control

16:22

of their own biology becoming better.

16:24

Stronger, smarter, faster and being

16:26

curious about it and doing it every

16:29

single day that was the idea for

16:31

a bio hacking conference, the first one ever

16:33

on the planet. That started on bar

16:35

napkin in San Francisco. That

16:37

small group has grown from less than hundred

16:40

people at bar to thousands of

16:42

people in L.A. or in Florida.

16:45

Come! Join me and like

16:47

minded people who want to be even

16:49

better human beings September fifteen

16:51

sixteenth and seventeenth and Beverly Hills, California,

16:54

for three days of awesome

16:56

community learning and playing.

16:58

With the big toys you learn from

17:01

dozens of experts and you'll get a fully

17:03

immersive experience in world that

17:05

has the latest devices and innovative stuff

17:07

you probably haven't had. A chance to see, yeah.

17:09

The get to talk to the people who make the gear

17:12

in the exhibition hall.

17:13

Then and you actually get to touch it and talk

17:16

with creators.

17:17

That's of all it's personal development, it's

17:20

a community is cognitive development, is

17:22

biological transformation, and

17:24

it's so much fun.

17:26

So to Biohacking Conference, dot.com com and sign

17:28

up now for your tickets, VIP preferred

17:31

and general are available and there on sale

17:33

that's three days September fifteen sixteen seventeenth

17:35

Beverly Hilton, I am so excited

17:38

to see there.

17:39

By now you've probably read something

17:41

from me or heard something from me about

17:43

n maybe you've episode five:

17:45

forty Four" with Caspar

17:47

Sulk from Innovative Medicine.

17:50

The clinic that pushes boundaries of

17:52

what you're supposed to be able to do in

17:54

medicine because they're doing biological medicine,

17:57

energy, medicine and even bio energetics,

17:59

which is how.

18:00

Body makes energy and one

18:02

of the biggest things they do is ivy in

18:04

a D treatments I've had about

18:06

twenty ivy and eighty treatments as part

18:08

of my anti aging regiment but. they've

18:10

taken a step further because they have comprehensive

18:12

in d supplement that you can take at

18:14

home is called not of them and

18:17

it's a clinical grade and eighty supplement

18:19

and one of the first nutraceuticals that uses

18:21

actual in d as their primary

18:23

ingredient instead of precursors and

18:25

eighty which are common in the industry

18:27

That of them combined in eighty with

18:29

nutrients and botanicals, things like the copa

18:32

Cola (Q ten) and Glycine that

18:34

are specifically designed to increase absorption

18:36

and make sure that is getting into your brain.

18:39

You can try it out yourself and you'll feel the

18:41

difference go to innovative medicine, dot

18:43

com slash dave and save twenty percent.

18:46

Dot innovative medicine dot. com

18:48

slash dave save twenty percent.

18:53

The that worked well with fasting does it work

18:55

better with as things that make fasting easier

18:57

or as it's something that you just you and depends.

19:01

Well. African studies cause the

19:03

trials of that were published, you alluded

19:05

to one of them in New England Journal of Medicine, executive

19:08

order from trials were published in a fast

19:10

frenzy. Around me and soon

19:13

or that dogs that da about

19:15

the role of smack the tide and individuals

19:18

with obesity, they were all studied

19:20

and individuals who are falling accelerate.

19:24

Die of the I was balanced, don't

19:26

lower and sugar in or eating healthy throughout

19:28

the day, it is not been studied to my

19:30

understanding, arms and within

19:33

her been fasting.

19:35

Got it, I imagine it would probably

19:37

make, and I'm in fasting even easier, although

19:39

with some of the other things you can do. That

19:42

that affect tetons, most people don't

19:44

experience hunger with intermittent fasting

19:46

or when they're when they're doing it right. This,

19:50

this new drug, though, about twice

19:52

as effective as other weight loss

19:55

drugs, and it was a

19:57

I kinda look at your how do change my food and myself

19:59

first? Would you add it to earlier but I'm

20:01

not above using a drug

20:03

to get results especially lifestyle doesn't work

20:06

and I would have happily taken this when weigh three

20:08

hundred pounds over done anything up?

20:10

to get that weight off That, what

20:12

are they? Possible side effects

20:15

that you've come across from doing this or is this

20:17

relatively safe?

20:19

Play. Twenty on limit, let me address to forthcoming

20:21

six, erasing a really interesting

20:23

points: obvious: "I see patients

20:26

in my practice and northwestern are

20:28

universal Chicago arts center for life some

20:30

medicines. Many individuals who

20:32

I see are hesitant to use the medication

20:35

to help manage their weight and item

20:37

our clinic it's not one hundred and my the

20:39

gold that may people think. That the

20:41

goes help people be healthier and

20:44

one of the metrics of health in

20:46

individuals is their weight becoming

20:48

healthier for their height or along with improvement

20:51

in the medical. Problems in, when

20:53

taught him about is that it's not

20:55

just will power or few just

20:57

you to discipline yourself, you

20:59

would be able to lose weight for individuals who.

21:01

Are struggling to wait for decades you

21:04

have to think of it like a condition or disease

21:06

let's see like diabetes. nothing

21:09

most people now understand of the developed diabetes

21:11

they don't just muscle throw it in trying to their

21:13

blood sugar down right they look for help

21:16

including medication to help with their blood

21:18

sugar in it i beat complication sweeping

21:20

obesity exact same way if

21:22

you have obesity are they are struggling

21:25

with for decades and yep other medical

21:27

problems if you think of the like a key medical

21:29

condition than it opens the door for

21:31

using medication on top

21:33

of lifestyle that's kind of how we dissonance

21:36

now we're not like with any medication dave

21:38

there's dearth rhythm benefits the benefits

21:41

are as you've already said his are

21:44

born in half to two times more effective

21:46

as smuggled tied that is than any

21:48

of the other medication said are approved for

21:51

chronic weight management so it is it's game

21:53

changer it's new direction kind of person

21:56

who have the drugs are like could be

21:58

developed to help people me Their. Weight,

22:01

but the risk our side effects

22:03

are all the job human hard

22:05

drugs that were like smack of ten years,

22:07

others in this category that for diabetes

22:10

pricked primarily. Of side effects that are gastrointestinal

22:13

and nature, or such as nausea,

22:16

diary around reflux

22:18

disease, constipation, some people even

22:20

vomiting nice are not fun things to

22:22

half, but we know by. How

22:25

we toast is how we use it, how he individualized

22:27

care, how we mirror healthy

22:30

diet with it, are we can mitigate

22:32

alavi side effects and most people in? The

22:34

trials completed to trial

22:36

do not drop out and actually tolerated drugs

22:38

very well.

22:40

I'm so they were they were worth it to so to

22:43

speak and.

22:45

For. People who've been obese a,

22:48

you'll go through a lot to get rid of it as long

22:50

as you can see results happening and it's

22:52

when you don't get results. And you've done you've

22:54

done the work that you start to feel really

22:57

helpless or just pissed off

22:59

I think went through both of those. and

23:02

I'd. I'd definitely

23:05

saw doctors and this is going back

23:07

on a while, but it was your maybe should

23:09

change your lifestyle, had him everything

23:11

that you can think of it didn't work. And

23:13

they didn't have good drugs other than maybe center

23:16

mean back them to never went on for.

23:18

does this compare that to the

23:20

to the to those types of drugs and how they

23:22

work and the bodies as so the

23:24

new and smuggler died if i'm saying

23:27

that ah rate like college

23:29

professor That's

23:32

glp one of fullness drug

23:34

had his of center mean work for the so called fenphen

23:36

that people talked about before.

23:39

So. The drugs that were developed arm

23:41

center mean with actually do with actually prove the United

23:44

States nineteen fifty nine, he could imagine

23:46

what our understanding of obesity was his

23:48

didn't know. For a minimal and

23:50

least for in front of me that the eyes intermediate

23:53

them as mean derivatives, everyone knows

23:55

what of sediments ourselves these drugs

23:57

work directly up in. The brain odds.

24:00

Make. You feel less hungry, arm

24:02

and it's derivative fellow,

24:04

mean, so there's very little addictive potential

24:07

but did, but people often develop tolerance

24:09

to it like you would take. And at mean, you

24:11

need higher doses, with course we don't do

24:13

that with obesity in other medications

24:16

or odd, we're developed that also

24:18

worked directly in the brain working on. Because

24:20

neurotransmitters doping mean serotonin

24:23

and norepinephrine directly up

24:25

and brain did, what would make

24:28

some smack with side and other trucks in this

24:30

area here has ever emerging so.

24:32

Different thing has new generation of is

24:34

that we now have much better understanding

24:37

of obesity, though the role of these got

24:39

hormones that come from the pancreas from

24:41

the. A test and, azad

24:43

help us in a more natural. way

24:46

i give a signals there were four

24:49

or less hungry for more kids has between

24:51

meals with less if we have craving

24:53

for thoughts of food and why people

24:56

think that's all under your own consciousness

24:58

your own will power is not it's actually

25:00

biologically driven so

25:02

just like diabetes in years

25:05

ago where we found out role of in spoil

25:07

with by giving him from which is unnatural hormones

25:09

which treat diabetes we know

25:11

our understanding door from bono regulation

25:14

of obesity in keeping those

25:16

hormones back i have much

25:18

higher doses than normal and work in

25:20

we're mimicking what would consider

25:23

more natural regarding the of the

25:25

tide regulation

25:27

Can you take is this is drug that you take

25:29

just once a week about

25:31

two point for milligrams, can you take

25:33

it for two weeks, lose ten pounds

25:36

for January and just

25:38

be done with it or something you take

25:40

for long periods time?

25:42

So we think of I'm like.

25:45

we said are ready and i'm in a reinforces with

25:47

think of obesity has to seasonally

25:49

at few more words to it seeks brown

25:52

The way up saying disease,

25:54

and if I substituted the definition

25:56

for diabetes use as my compared,

25:59

are all the time. We. Think of diabetes

26:01

as a lifelong problem: yes, you can go

26:03

into remission, but often with medication

26:06

or with significant changes in your lifestyle

26:08

become reemerge if you change your lifestyle

26:11

arm. If you go off of medications for

26:13

diabetes or hypertension, let's use the another

26:16

example: most people would pretty much

26:18

think your blood pressure go back operas or die before

26:20

verse undefeated. Maintain the

26:23

mit the drugs that put him in remission are in

26:25

control so obesity is exactly

26:27

the same thing these medications only

26:30

work when you take them in,

26:32

few. Gifts to have an excellent response

26:34

to smack what size of places. to

26:37

twenty percent body weight of which

26:39

by the way third of individual fair trial was

26:41

twenty percent body weight which supplement

26:44

almost fifty pounds and or i'm changing

26:47

It's. Like on one hundred of time

26:49

is like a six month's kind of thing,

26:52

sixty eight weeks sick, little over year,

26:54

little over year, okay? And and they were

26:56

just eating less where they also doing,

26:59

like the stuff they did with that,

27:01

the low fat such as you see way where it's meditation

27:04

exercise. Walking community,

27:06

oh, and the dietary change, or is this just

27:08

straight up, take the drug and go do your stuff?

27:11

A. Quick question: Everyone, what was

27:13

following a lifestyle change,

27:15

so what will I still miss with foundational

27:17

so we're focusing in on and

27:19

fuck from to watch therapy for obesity,

27:22

but? Just for all the listeners, the foundation

27:25

of healthy living is your lifestyle

27:27

and also for weight management of all

27:29

the subjects miss in the study came

27:31

in every single month. For dietary

27:34

and physical activity counseling medication

27:36

with added on top of that that,

27:39

seems like from confounding study.

27:43

with their control group the just had the interventions

27:45

without the drug correct or we have

27:47

to get to be teach these are all random

27:49

mutt week on randomized controlled, the urge

27:52

everyone to lifestyle counseling, one

27:54

group got the medication, yoga group got a placebo

27:57

right and week introduction, but placebo.

28:00

That would one of the concerns I had

28:03

that, and am this is a

28:05

Christian at curiosity, just

28:07

stick to it. It feels

28:10

like lot of the lifestyle advice on

28:12

that I receive and was overweight.

28:14

Was not achievable, oh, just you

28:16

don't eat less. Exercise

28:18

a lot more. Then I went out

28:20

and did it to the fullest possible

28:23

thing you can do about. it

28:25

seems that the as you mentioned earlier it's just

28:27

not going to happen So then you

28:29

have this, the study, were you say, okay,

28:32

go do this thing that's biologically I'm gonna

28:34

say either impossible or nearly impossible

28:36

to do? "They have another group where they

28:38

can do it because as a drug that let them do

28:40

it doesn't mean that the drug

28:43

is working or that mean that the advice itself

28:45

is flawed if it's something people can do with the not

28:47

on drop" While.

28:50

The requisitions have to be practical achievable

28:52

I call pragmatic right you don't want to fight

28:54

the or recommendations of people can follow

28:57

your point is well taken arms,

28:59

for everyone. Got the same exact fight people

29:01

on placebo lost about two point

29:03

twentieth presenter bodyweight it and of year

29:05

so every animal planet but dog,

29:08

and people on drug idea which. Was fifteen

29:11

percent or possibly remember the same

29:13

advice for to same, advice the

29:16

practicality though gets into

29:18

are just the mention of book wrote which is.

29:20

Called expect the said weight loss that works

29:22

for you" is it is a practical,

29:25

achievable approach to lifestyle

29:27

management, so I'm very much into

29:30

giving people recommendations that they can do.

29:32

Their head around out that is doable:

29:34

he'd given your lifestyle, not just some I

29:36

feel recommendations and

29:38

that matters a lot and

29:41

I in the early days of my weight.

29:43

Loss be going back even in into,

29:45

the nineties who heads

29:47

a and talk to these relatively

29:49

obese doctors told me. what to do anything

29:53

with it working for unit so we have to do as i say not

29:55

as do actually had a doctor tommy

29:57

those exact words i'm thinking

29:59

and The really idea and I don't know if can do

30:01

as you say so, what years you're showing here

30:04

though is people didn't comply? They

30:06

did with to now percent of their body weight. The

30:08

and. One perspective

30:11

on that is okay, that means that the

30:13

advice that we have their doesn't work very well.

30:16

Because even with monthly coaching and all

30:18

it will, they lose very much weight sites, my

30:21

take is that maybe that advice to be.

30:23

module waited and improved to a certain extent

30:25

whether it's with fasting or circadian

30:27

eating or changing the type of fats and all that

30:29

stuff.

30:31

But we've never tested any of those things in

30:33

conjunction with the drug, do

30:35

you think a rather be trial of keto

30:38

diet or cardboard I or

30:40

a vegan diet with some

30:42

good side or is it always

30:44

can be sort of the standard of eat less and?

30:47

Whatever else was in the recommendation be.

30:54

You know that mitochondria are the power plants

30:56

in your cells, but they're also something that makes

30:58

a bunch of other things like neurotransmitters and

31:00

proteins body needs their ground zero

31:03

for that energy, for how you age

31:05

and for your house. Hi, my nutrition

31:07

make supplement called might have pure to optimize

31:10

the way my mitochondria work it's got clinical

31:12

studies backing it to revitalize them.

31:14

Taking it every day supports

31:16

healthy mitochondria and muscle for the

31:18

and string.

31:19

We'll timeline nutrition dot. com Eastcote Asprin

31:21

ten and we'll give you ten percent off because you're listener

31:24

I'm on their year long plan that's timeline

31:26

nutrition dot com Eastcote Asprin.

31:30

You're listening to the human upgrade with

31:32

the of as free is it always can be sort of

31:34

the standard out he blasts and.

31:37

Whatever else was in the recommendations well,

31:39

i suffered for any investigators

31:41

work of the study anything at all yet so

31:43

that you know think individuals

31:45

or researchers are clinicians who

31:48

are really committed to a

31:50

low carbohydrate diet or intermittent fasting

31:53

will probably find their way to testing

31:55

drug along with i'm guessing yeah

31:58

no see that those types studies

32:00

I will die I'd love to work with Peter

32:02

a t on the since I got off the of McCall, his

32:05

one of the big low carb guys

32:07

are in a friend and.

32:09

It it's very interesting I'm in ask

32:11

your question that every researcher

32:13

a he's and.

32:16

and the normal answer is i don't know there's not a

32:18

study by if there

32:20

was study of this drugs

32:23

and say the keto diet

32:26

What would you predict the outcome of the study

32:28

would be it knowing that we don't have the

32:30

actual answer to that?

32:32

Her.

32:35

I. Don't I don't know what the effect

32:38

was don't notice sector, it's your p ones,

32:40

Rodgers in a key Tadic state, that's one

32:42

thing, and I both know so would.

32:44

Tell you that these drugs are examples

32:47

would be smuggled, tied, which treat me, my

32:49

believe this owes them back or to

32:51

wag with type which felicity these are

32:53

other drugs. On the market for diabetes, none

32:56

of them are proof for type one diabetes,

32:58

which in those who the individuals who are prone

33:00

to keep toasters so don't,

33:03

don't know. What the safety issues would be

33:06

using these drugs and someone develops

33:08

kids houses so that would be my first question

33:10

is, is it safe? Before we get

33:12

onto the effectiveness great.

33:16

It's true, I guess we don't know

33:19

we do know that Quito's is does also

33:21

affect g l p one. Then.

33:25

It's. One of the reasons that people are hungry on a cure

33:27

diet and some people say people is

33:29

waiting to test this because the less calories I

33:31

would say that's not true. Calais, least

33:33

on a person based as I tested using

33:35

Cuda with forty five hundred calories a day

33:38

and actually lost weight on that over the course

33:40

of several months, which didn't. Make any sense to me but,

33:43

it did it did work as

33:45

so not enough of an end. in

33:48

order to be valid but just enough to go

33:50

there's work to be done there

33:53

Is there a difference on new the strike with women

33:56

versus men because women express

33:58

your p one differently than men do?

34:01

There. There isn't that was looked at a lot will

34:03

all be calm baseline

34:05

variables for looked at regarding predictability

34:08

of weight loss arm and it turns

34:10

out that men and women out. There is no

34:12

statistical difference between the two

34:14

genders or between men and women, as

34:17

well as their or what you're starting be my

34:19

your bodyweight is, so it appears to. Be

34:21

effective across multiple demographic

34:24

can and new by biometric. The

34:27

variables are factors that they looked at wow

34:29

what about soda and status

34:32

and permit pause menopausal or

34:34

pre menopause and difference

34:36

there have not seen that

34:39

I. don't know either as it seeks in at information

34:42

out the things they looked our men women aged

34:44

by job arms i'd

34:46

miss city so forth and really was very

34:48

little difference between all of these

34:50

The panda there were no labs

34:53

and in terms of side effects you didn't

34:55

see anything bad happens it what I've

34:57

seen and all those that is that I read before

34:59

the interview. It was pretty

35:01

much. Then. Markers of cardiovascular

35:04

disease (H.B.A.) b a When see, which is something

35:06

that everyone should be tracking who's interested

35:08

longevity, you don't want to have high

35:10

average blood sugar over time. Because it's pro

35:13

aging through desk by case information,

35:15

although seem to improve.

35:18

Is it an anti aging drugs Lucius

35:20

so cities will be on the this such,

35:23

as taking it,? as

35:26

well i do as do miss knox you

35:28

just met you just talked about this and it's important

35:30

to mention as said this before that the

35:33

goal of weight loss not to meet people center

35:35

right it's all with a high towards health

35:37

so in these trials are critical

35:40

step trials that was third name

35:42

that are published under not only

35:44

did individuals lose weight but the guy who

35:46

were randomized or to the drug first

35:48

placebo but the also saw improvements

35:51

sugar control hemoglobin one see

35:53

what you just mentioned which is three month the average

35:55

of blood sugar improvement

35:58

in blood pressure in for

36:00

What? The outflanked like triglycerides

36:03

improvements, See er P, which is in the

36:05

slammer to a marker, hasn't been

36:07

in that is one of the top the recommendations

36:09

I am for longevity as. You have to keep your crp

36:12

low, some people found their crp

36:14

dropped, as just have them less white fat

36:16

making inflammatory molecules are, was there

36:18

some other of fact that? You think is there?

36:21

The opera forget the syrupy dropped

36:23

reader in those on the instruct gay

36:25

and he lost more weight so maybe to losing

36:27

more way okay but the but the newest

36:30

studies now are. suggesting

36:32

that Yeah. Mum

36:37

act on health and metabolism

36:39

beyond just appetites, an author like

36:41

there are a active, ongoing studies.

36:45

What would you say if someone

36:47

came in and said I'm on

36:50

an aggressive anti aging regimen I have these ten

36:52

stubborn pounds I've been trying to lose for a while I

36:54

want to try this for was if can gets mad your

36:56

body weight?

36:57

Would you support that

36:59

line of thinking, or would you say no, you're not a

37:01

morbidly obese, you can't do this?

37:04

I'm. I'm hesitant to,

37:06

you know, I'm hesitant use medications

37:08

someone to wants to lose ten more weights, a

37:11

ten more pounds or you're whatever

37:13

unit using I really

37:16

am A. Lifestyle management obesity

37:18

medicine specialist really look at totality

37:21

of the factors regarding health in.

37:23

someone is perfectly good health except

37:25

there ten pounds above

37:28

They. Are ideal weight are worthy

37:30

of that, their particular undermine with a one

37:32

way I'm pretty hesitant to start

37:34

using drug just to lose

37:36

ten pounds, I really have an eye. Towards

37:38

total health and I'm with

37:41

you there in spirit that

37:43

either are not that many people have ten pounds

37:45

to lose who can lose it using

37:48

the tools that. That work with I'm

37:50

unless it's tied to see react to

37:52

protein or homos is seen levels

37:55

or. some other inflammatory condition

37:57

as often times out of immunity or

37:59

the

38:00

Then. Favorite thing going on so few address

38:02

those, but just seems like this may

38:04

be another see reactive protein

38:06

lowering mechanism, and I

38:08

have seen a few cases where nothing

38:11

will lower. (CRP) Except for cryo

38:13

therapy, and we knew someone

38:15

who's lost hundred and fifty pounds

38:17

and is looking pretty good but

38:20

still has direct approaching them on drop that

38:22

would. Drop it but I wouldn't be

38:24

another doctor but if was it off wouldn't be opposed

38:26

to saying and give it a try if.

38:29

if normal other things don't work so can

38:31

you see some off label uses for

38:33

corner cases or as sort of things that so

38:35

new we should just keep it for really heavy

38:38

Then. First, what I'd like to I

38:40

am a citizen and scientists I like

38:43

to see the to equate previous day, but right

38:45

start giving it to people to bring down

38:47

there, see? Er Pizza, it there may be worthwhile

38:50

study to see her or his casino

38:52

lot of things in science

38:55

with sounded good and when he actually did the

38:57

trial, you. Got either in a negative

38:59

effect, your paradox or facts examples

39:01

come with cancer with vitamin C

39:04

(R), which was given quite some time ago,

39:06

were actually caused worsening of certain. kinds

39:08

cancers, so we we, we have

39:10

to get things as sound good, really

39:13

do need to be studied before we start using

39:15

them, can I I'm

39:17

with you there and it's? It's.

39:19

There's. A group of people who just get kind of desperate

39:22

and you've seen ten doctors and it doesn't work,

39:24

and you start looking for things to do

39:27

and I imagine. They'll be some people

39:29

I'm who end up going in this direction,

39:32

working with other their doctors,

39:34

and fully support the use

39:36

of drugs that might work as long as. The side effects

39:38

aren't that bad most likely but,

39:41

it takes a certain kind of doctor who is more the detective

39:43

than typical in this what we do and a. Hospital

39:46

or buy insurance things. up like

39:48

they vote as far as one thing and i said

39:50

before by lot of reinforced that against

39:52

his said all of the medications that we have

39:55

at least for obesity record chronic weight

39:57

management or anti obesity tribes

40:00

These drugs only work if you take the medication

40:03

in other words, the disease or the weight,

40:05

or the body fat comes back. When?

40:07

You stop the medication so now, like taking

40:10

something for a flu or further work for

40:12

wraps, if you're going to embark

40:14

upon taking medications, but the your example

40:16

of lowering. The see er p than

40:18

you really embarking upon a long

40:21

term use of that medication I

40:23

trump are risks and benefits and financial.

40:25

Then. Changes potential side effects we

40:27

haven't seen her before those

40:29

are all the things we have, the way have to

40:31

make your decision, can brew

40:34

say you doubling down on? That and also

40:36

want to go through, give you've written a book about

40:38

obesity you said he had for long time.

40:41

You identified six major

40:43

things that you're finding people who are

40:46

obese can. you run

40:48

through those things for listeners

40:50

so that know what you've seen

40:53

You're. So book called "Six Factors

40:55

to Weight" was to work for you, and if

40:57

just go to my one website, which is doctor Robert

40:59

Kushner, Dot.com, Doctor, is the are

41:01

Robert Dot.com. Read all about

41:04

hundred to blog to newsletters

41:06

and so forth, but the basis of

41:08

the book is practical approach, and

41:10

you in mentioned that earlier about not having ideal

41:12

thing the. , whole idea

41:15

the book is I a

41:17

saw people who losing weight you're

41:19

very successful losing hundred pounds, but then

41:21

more normal stories they

41:23

put the weight. Back on, and when

41:26

they saw one first after another what

41:28

I was thing they work the change something

41:31

and then when the gain you're weight, the went back to. Their default

41:33

behaviors or their default cognitions

41:36

you that can go them a into being

41:39

overweight and first, place so the

41:41

six factors are is identifying,

41:43

six different a. Behaviors

41:45

or cognitions or traits that people

41:48

tend. to fall into more

41:50

than one by the way they i gives

41:52

people a targeted approach the dealing

41:54

with the factor that is most

41:57

important to them that my being

42:00

Then. Weight gain are making it difficult for them

42:02

to lose weight, so just give you feel

42:04

of what I'm talking about, one of the

42:06

factors is great when and we give. Name

42:08

said he are easily understood, so

42:10

once called easily it's high speed or that's

42:13

factor in at describe someone is struggles

42:15

with eating temptations or

42:17

they may also have an. Emotional connection with

42:19

food that describes lot of people actually

42:22

in, few fall into that factor

42:25

the book or in the approach which

42:27

is whole chapter in itself. Gives

42:29

you strategies and targets

42:31

of what you can do with you identify

42:33

with their particular factor: I'll

42:36

just mention one other one to you, which is causing

42:38

all or nothing. Tour so this an

42:40

individual who tend to think and black

42:42

and white or academies thinking

42:44

like I'm going to work out for the on for the weekend

42:47

like like, "like a" [maniac] But Monday

42:49

only give myself break or I'm Nicole full

42:51

force in but the intermittent fasting,

42:54

but I'm going as the cases I missed stop doing

42:56

it's sort of kind. Of off and on

42:58

good in bed good and bad you know

43:01

of behave in that's enough of factor

43:03

lot people think about at the trait.

43:06

or as a whole chapter and hardaway seems

43:08

that thinking of their six of them

43:11

arm and when i found in

43:13

my study is that the heavier

43:15

you are the more like clear

43:17

to have more factors arm

43:20

and by losing weight and focusing and

43:22

inspectors these factors have to get under better

43:24

control say go in both directions

43:27

That is self help book, basically.

43:30

It. Always frustrated me, I'm looking

43:32

and similar comments from the Upgrade Collective,

43:34

some as an interview on where

43:37

we have a shot thread going by the guys, see you

43:39

just get a. Day of aspirin common sight of can be my

43:41

mentorship group and be in the live audience here

43:44

and, at branded saying in doctor's

43:46

often think patients are lying

43:48

or lazy because they're not following

43:50

that the sort of stuff but it i am found

43:53

predominantly when people aren't losing

43:55

weight, it it's because the advice. Isn't

43:58

very sick, isn't very good. Like you

44:00

can exercise away a potato chip, it

44:03

doesn't appear to be valid. If.

44:05

You look at the amount of time you'd have to spend on a treadmill

44:07

offered to bags of potato chips you

44:10

realize it doesn't work in exercising

44:12

the same amount of calories. From piece

44:14

of steak versus the potato chips

44:16

would have profoundly different results

44:19

and there's also did you that midnight

44:22

because, that's into it as well it's almost

44:24

like the advice of you change your behavior

44:26

vs

44:27

I'm change the inputs or changed the gut

44:29

bacteria that we're seeing can receive change

44:32

around understanding core biology

44:35

of obesity vs behavior of obesity

44:37

if he added sousa a percentage

44:40

of obesity that's behavior based Vs

44:42

biology best.

44:44

It could you take a stab

44:47

at where you'd put it with our current state of

44:49

knowledge?

44:50

Um. Both, are important obviously

44:53

um, but I i of, you

44:56

know, with development drugs like of

44:58

tide and more and more understanding

45:00

of obese the as. disease we

45:03

know think of more as, biologically

45:05

driven um that

45:07

influences your behavior, are your influences

45:11

obese your behavior influences your, biologically

45:13

that weight driven. your of

45:15

both of um are but it

45:17

more and biologically of the body

45:20

such as lose weight get hungrier

45:22

Or? If I have a tendency to gain weight

45:25

either to down regulation, my metabolism

45:27

or I may have a female type where are certain

45:29

food groups with the simple sugars

45:32

really the? White up my rewards and or and I can't

45:34

stop beating him or changes my metabolism

45:36

without honest and into biology if we're missing

45:39

a lot about how to help people. I.

45:41

won't let me add mom or think they are which gives

45:44

questionnaire listener said About

45:46

er doctors may think you're lying and so forth

45:49

on I think the medical profession

45:51

are rather than what you said Nitrous giving bad

45:53

advice would have a permit to carry no advice

45:57

I. think they're mostly are so

45:59

ill equipped And. Home in

46:01

have such lack of knowledge of they are, you know

46:03

what to say in instantly

46:05

pay the PCC eat less move

46:07

more, you know what to do I'm

46:10

I'm. "Honestly, five pounds off una you

46:12

back and month and it certainly is you sleep",

46:14

said when your arm is, "I know their hands

46:16

on the door number you to walk" On the roof know,

46:19

it's kind of like last minute come

46:21

into the patient so I am very

46:23

much involved in arm and

46:26

lifestyle and can obesity education

46:28

for. Medical students and residents, as per what do

46:30

with university, we are trying to

46:32

cheat hot train the next generation

46:34

of helped her professionals to be part

46:37

of the solution really. Understand

46:39

what is going on here are in Austin

46:41

and includes helping with regarding communication,

46:43

empathy most health professionals

46:46

are really don't know how to talk to someone

46:48

who is struggling with. Their weight by the way we

46:50

don't see obese people with a people

46:52

with obesity we don't label people

46:54

by their condition. i'm so

46:57

we've really try to help our learners

47:00

our to help patients in the united states

47:02

over seventy percent have overweight or

47:05

have obesity your how do you actually

47:07

help someone in very productive practical

47:09

way ah in it and it's new

47:12

for them and were trapped were working hard to try to get

47:14

there

47:15

Well. Thank you for doing that work,

47:18

educate doctors, a I've

47:20

run into some who really understand

47:22

weight loss and obesity and they work with

47:25

you on peptides and. Nutrition

47:27

and all, and they typically are, are functional

47:29

medicine people, small practice, but if you go into,

47:32

you are larger A. Then.

47:34

Neck it is it's, pretty hard

47:36

to find someone who really is gonna

47:38

work at work with you on those levels

47:41

vs wage sad, you know we'll try and.

47:43

Lose some weight in, go to the gym and the of

47:45

stop eating pizza, you'll be fine, I

47:47

and suddenly felt disrespected out

47:49

when started this pattern, but you.

47:51

Understand as, and everything

47:54

that you could think of ah and

47:56

the answers while you still try to lose weight In

47:59

in that didn't. Work in the with

48:01

you, educating the next generation doctors,

48:04

did to listen a little bit more think you're

48:06

going to it.

48:07

The improved the profession, but I get asked

48:09

about one other at one of the thing you mentioned

48:11

earlier, an interview. You said

48:13

that the died to his way it was

48:16

probably plant based, and

48:18

I was when it was that sort of a study

48:20

base and perspective right I

48:23

did not do well on a plane, his diet and effective.

48:26

The hundreds of thousands of people who worked

48:28

with my content didn't either, and

48:30

I'm kind of thinking that my be an industry,

48:33

preference not actually add medically

48:35

justified preference, where's your data

48:37

coming from or what's your take on that?

48:40

There's. Two kinds of data first

48:42

for every you, every one arm, everyone's

48:44

different right, we can phenotypes right so

48:47

the I wrapped about studies that have been

48:49

looked at AH where individuals.

48:51

Eyes are not vegetarians are busy,

48:53

but more plant based diet worldwide

48:56

not just in the North America and,

48:58

they have improvements in metabolic parameters

49:01

for the cardiovascular and points inflammation.

49:03

How and so forth, Mediterranean

49:05

diet probably has been studied more

49:07

than any other died, I'm familiar with

49:10

a globally AH regarding improvement,

49:12

encouragement about risk factors, so we

49:15

generally recommend our.

49:18

guiding people more to plant based diet

49:20

but didn't get what you're saying I tried

49:22

to be very practical with of with each patient

49:24

president and just this is how want. The

49:26

disguise you on one should eat or

49:28

in the nets the end the conversation, got

49:32

it and it is I'm a good feedback loops

49:34

as moon people sand isn't working. For

49:36

you and all so, there's

49:39

lot going on with hunger

49:41

of hormones which is new drug is

49:43

actually quite interesting of if

49:45

I was substantially.

49:47

obese and was losing weight the way.

49:49

i wanted are using techniques

49:52

that works including most

49:54

definitely and i'm in fancy improving sweep making

49:57

sure you move all that kind of stuff would

49:59

be compiled Really. Okay with,

50:02

with looking at the strike and thing as a candidate is

50:04

going to work because you're seeing people

50:06

as fifteen percent of their body

50:08

weight in year versus. Two

50:10

percent, or but you might be

50:12

list fifteen percent without the dragon like you should

50:14

try that beds for listeners this

50:16

is one of the things it's probably worth.

50:18

It because being obese like. that increases

50:22

risk factors for just about everything

50:24

i give you've gotta get that down

50:27

And. Joanne, from the upgrade going to the smell side

50:29

effects that looks like it's mostly nausea, but

50:31

there's not major life threatening

50:33

for some Gee I side effects, but there's no systemic.

50:36

Cancer and things like that are going up not,

50:38

not that have been seen that DJS

50:40

i effects which we met him before are usually

50:43

become tranches. And Can Miles has

50:45

cut out there were describes as long as you're on the

50:47

troika we don't escalate it's slowly

50:50

over the first four months to start love built

50:52

up or. And you're able to manage

50:54

lot of them though, the one metre

50:57

got enough for side effects but when medical

50:59

effective saying is that individuals

51:01

in drug trials develop slightly more.

51:03

Gallstones or gallbladder related

51:05

problems for they got gallstones

51:08

and you to gallbladder taken out part

51:10

of it may be to drug part of it, maybe they

51:12

lost more weight with we. Know the West people

51:14

lose more weight big, they have an increased risk

51:16

of developing call stones on,

51:18

but other than the out there were no

51:20

other medical ah complications

51:23

that. We're, same time in

51:25

his drug. was originally harm

51:27

put in the market quite some time ago for

51:29

maybe five or six years ago as a diabetes

51:32

drug or as i mentioned before the trade

51:34

name is called those ended at a lower

51:36

dose ah this is higher dose

51:45

Diabetes and that lowers the risk

51:47

quite a lot when something's going on the market for

51:49

five or more years and you,

51:51

actually have an idea of what it's

51:54

what it might do in large populations who use

51:56

it versus just kind of rushing something to market.

51:59

In end.

52:00

Giving. It everywhere in the noticing, a might be side effect

52:02

couple years later and good

52:04

image, Reuters dad or David drug,

52:07

or the lower dose of smack the. tide was

52:09

studied and out we call cardiovascular

52:11

outcome trial, call the See Fealty,

52:14

where you take out large population

52:16

of individuals over years, five years

52:19

or more in your randomized. Half individuals

52:21

who are already at risk, they have diabetes, the

52:23

of hard to see the it, they're already high risk

52:25

versus placebo in the trial

52:28

individuals were randomized as. Lower dose

52:30

smack of tights have lower risk of

52:32

cardiovascular disease and

52:34

death at the end of the trial of not

52:37

only does it approved body weight and curvy

52:39

be a. Risk factors, Darnell studies

52:41

show it actually improve cardiovascular

52:44

death. "Over the over the lifetime

52:46

awesome seeking truck stops me

52:48

from it's like drugs are showing that now, but desk

52:51

another nother are important

52:53

marker of regarding nothing that words

52:55

really looking towards health and longevity

52:57

and not just wait asked"

53:00

That. It is a really exciting, really

53:03

exciting, I caught a break your weight loss

53:05

drugs from what I've seen in

53:07

this study's it looks safer because

53:09

we've played around that for. Diabetes for long time

53:12

and there are good number of listeners

53:14

of this of the show because

53:16

I talk about one seventy and as got to

53:18

high. Performance so we've got a bunch people in their

53:20

twenties who are just killing it in

53:22

their careers and lives and with kind of and people in their

53:24

sixties and seventies for. Also to join

53:27

it and there are some lives but are lucky and

53:29

blood sugar regulation more seriously ah,

53:31

so If you're looking at soon

53:34

as relatively high blood

53:36

sugar may be on the borderline of diabetes

53:38

and working really hard on it and some extra

53:41

pounds. This might

53:43

be an appropriate intervention for them. No.

53:46

So we have an earlier study which is

53:48

called Diabetes Prevention Program

53:51

or TPP done got twenty

53:53

years ago or so, which showed

53:55

if you take individuals with three diabetes,

53:57

so it's people are idea Graystone that. Normal.

54:00

Much been now diabetes in,

54:02

if you if you a interview with

54:04

that with lifestyle treatment alone,

54:07

you could reduce the risk diabetes by

54:09

on fifty eight percent, which is really. Significantly

54:12

we also know by giving drug of like Metformin

54:15

you can also reduce the risk of developing

54:17

diabetes, this

54:20

type of drug this deal people has also

54:22

being. shown to reduce the risk developing

54:25

diabetes in someone who has

54:27

pre diabetes another

54:29

study which when three years with another

54:31

type of deal, people someone answer

54:34

questions along went. It answer if

54:36

that we are now being much

54:38

more aggressive in working with individuals

54:40

with, pre diabetes along

54:43

with lifestyle counseling using medication

54:45

went indicated to prevent the. occurrence of

54:47

diabetes pre has along

54:50

that that's really big deal

54:53

for people who been this working on this for years

54:55

giving really the prevent the is we

54:57

of lot of this no who are using the

54:59

level

55:01

Blood glucose monitoring system is that on

55:03

occasion I and was

55:06

pre diabetic in my mid twenties and don't

55:08

have issues with the now, but do look in effect

55:11

on sugar. What about

55:13

a if someone came in you who is very

55:16

heavy missing I'm looking gastric bypass

55:18

surgery would you generally recommend

55:20

trying some? good time

55:23

before gastric bypass surgery would

55:25

you combine the two together

55:29

Great question and we didn't talk about barrier

55:31

to surgery, but if we think of obesity

55:34

just as of as a framework, party think of

55:36

obesity or as crime. The

55:38

lapsing condition and we use medical

55:40

model. One of those pockets

55:43

or one no treatment arms experience

55:45

with surgery right the nets gastric bypass

55:47

suggest for sleep of the two most commonly does

55:50

so. we use those treatments

55:52

are all the time and someone with severe obesity

55:55

multiple medical problems are

55:57

they have tried multiple other mortality

55:59

without six He. Had and they would benefit

56:01

from interventions, the will recommend

56:03

Garriott, your search, your question is,

56:06

would be all to tray medication

56:08

before marriage surgery, the answer

56:10

is potentially yes, depending. Upon

56:12

the interest of the individual spoke

56:15

I tell them right up front that it,

56:17

is it's usually are not either

56:19

or armed, people

56:22

often one I'll take the. medication by

56:24

what the outcome of Bioreactor, surgery

56:27

and i can promise that guzman medications

56:29

very effective but it

56:32

on the average does not cause the same

56:34

results experience with surgery is more

56:36

but hundred intermediate between

56:38

lifestyle and bury utrecht surgery

56:41

we often to combine them which is the last

56:43

thing you mentioned will have patience to who

56:45

have had periods or surgery but are not

56:47

responding in the weeks ejector

56:50

either we would expect them to lose so

56:52

what he had medication in others

56:54

we may use medications before barry

56:57

up six surgeries in order in order to

56:59

reduce their curry upper to frisk right

57:01

to risk of going through the surgery so

57:03

we are combining these more

57:05

the out more and more know

57:08

And that's.

57:10

That's really interesting, so you could you both,

57:12

and it's probably not harmful to try

57:14

the drug first.

57:16

No. Helps out harmful, it doesn't, it

57:18

doesn't dog, oh, are

57:21

you know, reduce the likelihood that you would benefit

57:23

from surgery or you are you winky

57:25

candidate for surgery if someone

57:27

is? fairly overweight, I

57:30

can we think there are a high medical risk will

57:32

often used medication before surgery

57:34

in order to help them be more functional

57:37

of reduce their of download girth. Biggest

57:39

surgery certain have to go to the abdominal

57:41

area where love the fat, his arm

57:43

get them, it's deeper press gift or diabetes

57:46

and her brother control, so we just. We can improve

57:48

their performance and improve their medical

57:50

condition prior to surgery

57:52

by using medication along with lifestyle.

57:56

Okay, I liked as an ad

57:58

deborah from the upgrade collective has.

58:00

A really interesting question here and you

58:02

have these sort of six factors

58:04

at the person development site, a weight loss.

58:08

Is. A drug like some

58:10

a good side going to work for

58:12

someone who's maybe as the easily and hi cedar

58:15

better than someone who's and exercise

58:17

straggler I did doesn't work for. Emotional

58:19

eating does it work for all car proceedings

58:23

a, great cook various it for Christmas

58:26

is over thank you for a up in that are

58:28

so we've done this. Kind of work within our own

58:30

program in what we found if you

58:32

take those six factors. ah

58:34

man from and scores very levels

58:37

of i'll all these different factors week by week

58:39

you can go on my website and seek to quit yourself

58:41

for free and it's and it's course that

58:44

automatically attacked rapper push comes

58:46

to get to go and do that's what

58:48

we have found that the one factor that seems

58:50

to be exquisitely sensitive

58:53

to use these medications disease may

58:55

entice dieter Reducing the

58:57

temptation and it's height from enough food

58:59

by changing appetite. Then.

59:02

At factor score plummets because

59:04

they're not stay, I say have

59:06

affected by food the, exercise

59:08

struggle or which is another factor is

59:11

not gonna be are directly affected

59:13

by. The drug, however, if one is losing

59:15

weight, think they do test this guess you'll

59:17

lose weight, you really good theory motivated

59:20

to take better care of yourself, you may actually

59:22

engage. In even more physical activity

59:24

one because you're motivated and you have an insert

59:26

the number two because you can. write

59:28

i've patients all the time who never

59:31

even thought of seeking a hydra going for weekend

59:33

walking on path or taking

59:35

up cycling klaus are doing ballroom

59:37

dancing whatever it is in so they've

59:39

lost the weight and now they could start seeing

59:42

things to do that in never even

59:44

imagined because their bodies they were

59:46

functional they they're short of breath

59:48

in feel good about themselves so

59:50

is it indirectly will increase

59:53

the factor the axis i struggle or because

59:55

they are losing weight and feeling better about

59:57

themselves What about the costs?

1:00:00

And even that the low dose for diabetes

1:00:02

it's about eight hundred bucks I

1:00:04

think for month's supply, AH, at

1:00:06

the minimum of two, about a thousand

1:00:08

dollars.

1:00:10

This. Is covered by insurance for most people it

1:00:12

that's a scary, scary paper, and you

1:00:14

just said the eyes of the

1:00:17

one of the arms when

1:00:19

live in that the biggest challenges.

1:00:21

And barriers to use medications

1:00:23

or obesity is coverage AH,

1:00:26

Middle East and Canada courses in bit

1:00:29

different the United States you. vip

1:00:32

thirty years you have to. Private insurance

1:00:34

and or take cover these medications good

1:00:36

none of our government on search nice cars,

1:00:40

around your, medications to

1:00:42

you really need to have park hopper it's

1:00:44

your. Insurance reimbursement for these medications,

1:00:47

which is your it, he said, can be hundred

1:00:49

dollars or north of eight hundred dollars every

1:00:51

month, which is to be on the reach

1:00:54

of. Really any human being's arm

1:00:56

and that the in and answers

1:00:59

are, often hesitant to

1:01:01

cover these medications because when they've

1:01:03

looked at the under thirty million

1:01:05

or more Americans who. Had to

1:01:07

our core potential, candidates

1:01:10

these medications they don't know how

1:01:12

they're gonna have their how they can afford it's

1:01:14

so as to the often just don't offer

1:01:16

these. medications of release so

1:01:19

are correct rant ready kind of fork

1:01:21

in road where we are developing more

1:01:23

and more active medications like some echo

1:01:25

ten years author's. Coming down the road

1:01:28

arm by yet different

1:01:30

gonna corporate, ah,

1:01:32

we're what's the financial cost of they

1:01:34

had to talk to do, so he had her think

1:01:36

we need to come. To arm. and agreement

1:01:39

and resolution they had to obesity

1:01:41

said disease as we said before

1:01:43

his eighties seeds and many other chronic

1:01:45

diseases las vegas control obesity

1:01:48

all eat or medical problems are going to continue

1:01:50

and we've got to develop

1:01:52

funding identify funding of how

1:01:54

waist or to support the computer

1:01:57

these medications are so he and individuals

1:01:59

who are

1:02:01

The other option is, you know,

1:02:03

if you're going to spend zero four thousand

1:02:05

dollars on medication,

1:02:07

which is couple him into effect does for a

1:02:09

few months, you could probably

1:02:12

fly to Mexico.

1:02:14

And back for thousand.

1:02:16

dollars and cover your hotel and

1:02:18

go to a pharmacy there in buy it for lot

1:02:20

less or to thailand for that matter and

1:02:23

there's lot people doing that right now just

1:02:25

i'm saying this mostly for listeners where

1:02:28

prices for drugs in the you s are outrageously

1:02:31

high compared to almost every country on the planet

1:02:34

you are also legally allowed to import

1:02:36

a three month supply of

1:02:38

just about any drug i'm if it's

1:02:40

not on unscheduled substance from

1:02:43

out of the country as long as younger

1:02:45

doctor's prescription even if the doctor's out of the

1:02:47

country so this is how people including

1:02:49

me when as younger who couldn't afford certain things

1:02:51

could make it affordable i don't know how available

1:02:54

this is internationally but is this drug that's

1:02:56

globally available now are that mostly a you s

1:02:58

in europe

1:03:01

It. Is, available in

1:03:03

a blue to develop on Canada's well in North

1:03:05

America, Hi is coming online

1:03:08

really country by country or region by

1:03:10

recent side on the how many countries.

1:03:12

Have it approved now he was approved the United

1:03:14

States harm him on, the

1:03:17

confusion, of twenty one

1:03:20

and it's coming line in other countries I

1:03:22

think. All, time beautiful oh

1:03:24

Bob appreciate your

1:03:27

your. mom studies of obesity

1:03:30

and all the others as you diseases

1:03:33

and looking into the myself factors which

1:03:35

is something that have a lot of medicine

1:03:37

hasn't done your brain and medicine and particularly

1:03:39

looking at pharmaceuticals like this

1:03:41

that appear to have low incidence of side

1:03:43

effects and very high efficacy

1:03:46

and so because if you listen to this going

1:03:48

yeah i know dave was hundred pounds know people lost

1:03:51

a million pounds on the board retired

1:03:53

centers address or it's not working

1:03:55

for me and i gave it a real try and

1:03:57

there is no moral or ethical

1:04:00

Thing preventing you from doing anything

1:04:02

available to you to get the results you want with

1:04:04

a risk you an and I'm fully in

1:04:06

support of using pharmaceutical

1:04:08

that's reducers. risk of doing

1:04:10

from all causes i think that's very valuable

1:04:13

thing and this a so appetite

1:04:15

look to be really interesting

1:04:18

if you can afford right now like

1:04:20

all drugs of is most drugs over

1:04:22

time when you don't have monopoly powers granted

1:04:24

by the us government do decrease in

1:04:27

price over time also

1:04:29

this tells the bakers amongst

1:04:31

us that just be one

1:04:33

might be something to look at if

1:04:35

you of problem with appetite and i would

1:04:38

just tell you to can toss this

1:04:40

and factor thing which induces

1:04:42

kato this induces also has and in factor

1:04:44

and your be want us one of the many reasons you're less hungry

1:04:47

and when you that so that might be a factor

1:04:49

to have even if you don't

1:04:51

either need the drug or want to

1:04:53

use the drug or just don't have access to the drug

1:04:56

so this so i think as an new tool

1:04:58

for those of us who are a be at

1:05:01

the when one to us and i really

1:05:03

again think you by for can an the show can

1:05:05

you give me you're you or all when time from want new

1:05:07

or valuable

1:05:09

Some. Show on to podcasting

1:05:11

your podcasting got for is you're to

1:05:13

your listening beautiful,

1:05:16

things being on the show because

1:05:18

thanks for being in the audience upgrade collective

1:05:21

and if you're. Listening to this on whatever your favorite

1:05:23

podcasting platform is and thank

1:05:25

you for following the show

1:05:27

for subscribing to the show and for subscribing

1:05:30

on some the to and if you. And about

1:05:32

podcasting got to favorite, which

1:05:34

a got because, and to you

1:05:36

for this is in overeating

1:05:39

book about in and thanks you got to collective listening,

1:05:41

some is which. Because he's got book about some lifestyle

1:05:43

things and the lifestyle and overeating

1:05:46

which. thank The

1:05:48

you.

1:05:50

You're listening to be human upgrade with

1:05:52

the of as free.

1:05:58

You're

1:06:00

listening to the human upgrade with Dave Asprey.

1:06:03

The human'a paid. paid The only will

1:06:06

approve radio was created in is hosted.

1:06:07

Dave Asprey, executive producer himes

1:06:10

audio video engineer Chris McLaren Podcast

1:06:12

coordinator Bev Hampson. The

1:06:14

information contained in his podcast is provided

1:06:16

for informational purposes only and it's not intended

1:06:18

for the purpose's attack. In treating curing

1:06:20

a preventing any disease before using

1:06:22

any products reference on the podcast, consult with

1:06:24

your healthcare provider carefully. The only both

1:06:27

in heat all directions and cautions that occur. Then.

1:06:29

Product information found receives

1:06:31

to the podcast shouldn't be used in place of consultation

1:06:33

or advice from health care provider if

1:06:35

you suspect you have medical public or should. You have

1:06:37

any healthcare questions, please public policy,

1:06:39

your healthcare provider that podcast,

1:06:41

including Dave Asprey and the producers. Then.

1:06:44

Responsibility for any possible adverse effects

1:06:46

from the use of information contained herein abundance

1:06:48

of get through their own in his podcast is not endorser

1:06:51

accept responsibility statements made by guess

1:06:53

that. Packers does not make any representations warranty.

1:06:56

Podcast Qualifications for Credibility This

1:06:58

Podcast may contain paid endorsements and advertisements

1:07:00

for products of services.