0:00

of the things that I'll say

0:02

we didn't know a lot about

0:04

back in 2011 was the ideal

0:06

length of a fast. And so

0:08

what I found is we want

0:10

to probably go 18 hours and

0:12

I talked about some longer fasts.

0:14

But then people were over -fasting

0:16

and creating biological stress, almost a

0:18

starvation response. If I start taking

0:20

Mimeo, this carefully constructed blend of

0:22

four things, can I stop fasting?

0:24

Nature has given us a lot

0:26

of these very interesting regenerative states

0:28

So the body regenerative pathways that

0:30

our body naturally uses to heal ourselves.

0:33

The nice thing about the Mimeo formulation

0:35

is that in addition to the clinical

0:37

studies that we've done on the full

0:39

formulation, the individual ingredients have like 100

0:42

plus clinical studies out there already on

0:44

them showing they have all these various

0:46

effects. For the lifespan extension, for example,

0:48

PEA was able to extend lifespan by

0:51

24%. OEA was able to extend lifespan

0:53

in that same range, like 28%. Is

0:55

it true that you've extended lifespan by

0:57

96 %? You're

1:00

listening to the Human Upgrade

1:02

with Dave Asprey. Chris,

1:06

I'm really excited to have you on

1:08

the show because a lot of listeners

1:10

know back in 2012,

1:14

I started writing about the

1:16

Bulletproof Diet, which was, I'm going

1:18

to say, the first modern intermittent

1:20

fasting diet. I ran a couple

1:23

big books about fasting and a

1:25

big book about longevity. And

1:27

you're coming out of

1:29

UC Davis and you've

1:31

really studied biochemistry and

1:33

you're now looking at details and fasting that

1:36

no one has looked at throughout history. Is

1:38

it true that you've

1:41

extended lifespan by 96 %? Yeah, that

1:43

is true that you've extended lifespan by

1:45

96%. In what? In C. elegans. Yeah.

1:47

Okay. So, you know, we'll put that

1:50

in perspective for people, right? That's like

1:52

nematode worms, but it's also a really,

1:54

really common methodology for measuring lifespan extension,

1:57

right? And the cool part about being

1:59

able to extend lifespan by 96

2:01

% with Mimeo is that

2:03

when you compare that to

2:06

longevity drugs like rapamycin or

2:08

metformin, right? Metformin can

2:10

extend lifespan by 36 % in

2:12

C. with some downsides. Yeah, with

2:15

some downsides, rapamyzing can do it

2:17

by 19%. So Mimeo, this natural

2:19

combination of these molecules that our

2:22

body naturally produces during fasting, being

2:24

able to extend it 96 %

2:26

with no side effects, that's pretty

2:29

remarkable. One of the things that

2:31

I'll say we didn't know a

2:34

lot about back in 2011, 2012

2:36

was the ideal length of a

2:38

fast. And so what

2:40

I found is you want to probably

2:43

go 18 hours and I talked about

2:45

some longer fasts. But then people were

2:47

overfasting and creating biological stress, almost a

2:49

starvation response. So I followed up with

2:51

fast this way to talk about how

2:53

do you adjust the length of your

2:55

fast space and your biological state and

2:57

your goals. But you've

2:59

gone way deeper since then. What

3:02

is the magical number for a fast?

3:04

Yeah, that's a great question. When you

3:06

look at the clinical research into it,

3:09

the magical number really seems to be

3:11

kind of this 36 hour mark. So

3:13

that's typically what you would experience during

3:15

alternate day fasting, which is where we

3:18

see in the data, you get the

3:20

best lifespan extension and typically where you

3:22

get the best health span extension as

3:24

well. So it's basically one day of

3:27

normal eating, one day of complete fasting,

3:29

rinse and repeat throughout the entire organism's

3:31

lifespan. And that's where you'll see these

3:33

really great impacts without a lot of

3:36

deleterious side effects, if any at all,

3:38

from the fasting. So you

3:40

eat every other day? I don't

3:42

anymore. I did do that.

3:45

That's part of my journey with fasting

3:47

was after I got out of college,

3:49

got my BS in biochemistry from Loyola

3:51

Marymount University, didn't know what I wanted

3:53

to do, took an immunology fellowship at

3:55

Stanford where I just kind of started pouring

3:57

through papers and got really into fasting that

3:59

way because, you know, I don't have to

4:01

tell you. There's one thing

4:03

that helps with everything, helps to treat prevent and

4:05

delay most major diseases, but then also one of

4:07

the only ways that we know of to extend

4:09

lifespan. So I was learning

4:12

all of these immunological techniques and

4:14

I just started fasting myself. I

4:16

was like, all right, I can

4:18

do this, right? I can fast

4:20

for 12, 24, 36, 48, 60,

4:22

72 hours and just kind of

4:24

track what happens to myself throughout

4:26

that time course. And that

4:28

was... impactful for me because

4:30

I could see, all right,

4:32

after 36 hours, after 48

4:34

hours, there was this progression

4:36

of improved cellular functionality. And

4:38

my cells became more anti

4:40

-inflammatory, more resistant to stress,

4:43

you know, better longevity, better

4:45

metabolic functionality. So really,

4:47

really cool, very quantified self for a

4:50

scientist to be able to see that.

4:52

And then that's kind of where I

4:54

got hooked on. And I was like,

4:56

okay, I'm going to do alternate day

4:58

fasting. And I did that basically for

5:00

two years, but eventually got to the

5:02

point where, you know, it's really beneficial

5:05

for your health, but really impactful in

5:07

a negative way for your socialization, right?

5:09

You're not having those meals with co

5:11

-workers, you're not having meals with family.

5:14

I had plenty of interactions with my friends where

5:16

it's like, oh, like come out to dinner with

5:18

me. And I'm like, well, it's a fasting day.

5:20

So I'll come and I'll like, you know, drink

5:22

water in front of you while I stare at

5:24

you while you eat. And that's just like not,

5:26

you know, not the best. Nobody really wants to

5:28

do that. So I got to the point where

5:30

it just wasn't viable as a long term. thing.

5:33

So that's one of the reasons why

5:35

I got to the point of wanting

5:37

to try and create something like Mimeo,

5:40

figure out what's happening in the body

5:42

during these periods of fasting that are

5:44

activating these beneficial effects and find some

5:46

way to recreate them. What

5:48

are the beneficial compounds that the body produces

5:51

during a 36 hour fast? There are a

5:53

lot of them. So when we looked at

5:55

it, we had 20 people come in, 10

5:57

men, 10 women to avoid a gender bias,

5:59

and we had them fast for 36 hours.

6:02

And what we found was

6:04

that there were over 300 significantly

6:07

upregulated metabolites in the body

6:09

during a fast. And

6:11

when we screened through those molecules,

6:13

we found around two dozen or

6:15

so that had some kind of

6:17

literature result of having bioactivity, whether

6:19

or not that was creating anti

6:22

-inflammatory effects or inducing autophagy. And

6:24

then once we screened through those,

6:26

we did kind of, you know,

6:28

individual ex vivo modeling to look

6:30

at how these metabolites impacted the

6:32

cells. We found that there were

6:35

the synergistic combination of four of

6:37

them that we could use to

6:39

replicate all of these beneficial cellular

6:41

health effects of fasting. And like

6:43

we already touched on, we could

6:45

extend lifespan by 96%. So the

6:48

ones that Mimio is working with

6:50

are nicotinamide, spermidine, palmitol, ethanolamide,

6:52

and oleol, ethanolamide. But then of

6:54

course there's a bunch of others

6:56

as well that we kind of

6:58

know about, like ketone bodies. And

7:00

then we don't really know about

7:02

all that much, like palmitolyic acid

7:04

and these other ones that don't

7:06

have a ton of scientific research

7:08

behind them or don't have any,

7:10

and that we, as part of

7:13

our research platform and part of

7:15

our product discovery platform, are looking

7:17

at on the back end to

7:19

see if we can develop more

7:21

synergistic... like the Mimeo

7:23

Blend or these new wave

7:25

of clinically derived health and

7:27

longevity molecules that have an

7:29

immediate context within human health

7:31

because they come from us.

7:34

I was really interested in

7:36

spermidine. I wrote about it

7:38

in Superhuman, my big longevity book. And at

7:40

the time, you could not buy spermidine in

7:42

the US except as a research chemical. It

7:44

was very expensive. So I

7:46

took a probiotic that I kind

7:48

of illegally imported from Japan. in

7:50

order to raise my spermedine. And

7:53

the first company that brought spermedine

7:55

to the market came on the

7:57

show and launched. And I

7:59

was so excited to do it. And I still take

8:01

spermedine every day. And I even

8:04

stopped fasting for a while to see if I would

8:06

still get the benefits. And I think spermedine is good

8:08

for you. In fact, I know it is. But I

8:10

didn't seem like I was getting the fasting benefits from

8:12

it, just spermedine. So it's a synergistic thing that's a

8:14

combination. Yeah, absolutely. So spermedine

8:16

really is going to be focusing on

8:18

autophagy, right? Which a lot of people

8:20

think of as it's the main benefit

8:23

of fasting. But in reality, what fasting

8:25

is doing is activating this very, very

8:27

complex, what I like to call bioprogram.

8:29

So you have a lot of different

8:31

pathways that are being activated on the

8:34

same time and they're all going to

8:36

be complementary and synergistic with each other

8:38

because you know, that's how biology works.

8:40

We have to get through a lot

8:43

of, you know, positive and negative feedback

8:45

loops in just the right combination of

8:47

activation and deactivation of pathways to achieve

8:49

a specific effect. So when you're doing

8:51

something like single sperm -redine supplementation... that's

8:54

going to be affecting the autophagy pathways,

8:56

but it's not going to be affecting

8:58

other things that also happen during fasting,

9:00

like the NAD CERT pathways, or Ampkinase,

9:03

or, you know, P -Pars and lipidoxidation

9:05

and things like that. So you really

9:07

need to create a more holistic picture

9:09

to kind of get the cell over

9:11

the hump and create more of these,

9:14

you know, stacking beneficial effects. And

9:16

one of the things that I kind of appreciate In

9:19

the Mimeo stack that you've developed

9:21

with all the statistical analysis you're

9:23

doing, it's Niacinamide. And

9:26

as an old school longevity guy, 25

9:28

years, this is what people have been

9:30

taking for 40 years. Absolutely. And in

9:32

the way it works, and other gas

9:34

debits and clerks have been on, and

9:37

just recently had another whole discussion

9:39

about NAD with the guys from

9:41

Wonderfield. And it's like, okay,

9:44

you have Niacinamide and you have NR.

9:47

then you have NMN, which goes

9:49

to NAD, and you can inject

9:51

NAD, or you could take any

9:53

of those things and niacinamide is

9:56

like the old school molecule. Why

9:58

did you choose that versus another

10:00

NAD precursor? Yeah, we chose nicotinamide

10:02

because we found that nicotinamide itself

10:04

was upregulated during fasting in circulation.

10:07

But then we also found that

10:09

one methyl nicotinamide was highly upregulated

10:11

during fasting as well and even

10:14

more than nicotinamide itself. And in

10:16

addition to, you know, NR, NMN.

10:19

Nicotinamide is also the precursor for one

10:22

methyl nicotinamide. So it's even more downstream

10:24

of that path. And one

10:26

methyl nicotinamide has been shown to

10:28

have these really interesting kind of

10:30

like myokine effects. So muscle enhancement,

10:32

performance enhancement, cardio protective effects and

10:34

anti -inflammatory effects. And we saw

10:36

that all throughout the cellular data

10:38

that we were doing as well.

10:40

So we use nicotinamide because it's

10:42

going to give you basically everything

10:44

downstream in that stack. So when

10:46

you take nicotinamide, your body's gonna

10:48

make nicotinamide riboside and it's gonna

10:50

make NMN and it's gonna make

10:53

NAD and it's gonna make one

10:55

methyl nicotinamide. So you're kind of

10:57

getting everything all from this one

10:59

thing that is also significantly, you

11:01

know, less expensive and has a

11:03

much better clinical history than NR

11:05

or NMN. There's no reason you

11:07

couldn't do both, right? Oh, yeah,

11:09

no, absolutely. Yeah, since they're all

11:11

running through the same pathway, you

11:13

can stack as much as you

11:15

like. Okay. One of the

11:17

things in biochemistry that you can

11:19

do is you can add either

11:21

a methyl group or a phenol

11:23

group to almost any molecule, like

11:25

phenolgaba, is a pretty darn potent

11:27

for sleep. In fact, it has

11:30

pharmaceutical effects and it's a little

11:32

addictive. Why

11:34

don't you just make methyl nicotinamide

11:36

and put it right in Mimeo?

11:38

Yeah, there is a complicated story

11:40

about that. It kind of gets

11:42

into the weeds of some of

11:44

the silly things that the FDA

11:46

does. But the reason why we

11:48

don't use one methyl nicotinamide directly...

11:51

is because there was another company

11:53

that took one methyl amniicotinamide or

11:55

tried to take one methyl amniicotinamide

11:57

down the IND pathway as a

11:59

drug development. Yeah, exactly. So

12:01

they got all the way up to the

12:03

phase two studies, you know, big human trials,

12:06

and they... the for the disease state

12:08

that they were looking at didn't find

12:10

that the dosage, which was really low

12:12

of one methamphetamine they were using had

12:15

enough of an effect to qualify as

12:17

a drug. So then the FDA was

12:19

like, oh, sorry, it's not a drug.

12:21

They shut it down. But because of

12:23

the rules of the FDA, any molecule,

12:25

even if it's a natural molecule that,

12:27

you know, exists inside your body and

12:30

basically every cell in the living world,

12:32

even if it's that, if it's ever

12:34

gone down the IND pathway to a

12:36

certain point, then it can no longer

12:38

be sold as a supplement. So

12:41

this, a one methylnegotentamide is now being sold as

12:43

a supplement in Europe where the original company is

12:45

based, but now it's kind of just locked out

12:47

of being sold as a supplement in America. Well,

12:50

there may be a new sheriff in town,

12:52

Bobby Kennedy. If you're listening, thank

12:54

you if you are. If not, I know lots of

12:56

your friends are. So since you're

12:59

running the FDA now, maybe we

13:01

could just set aside this policy

13:03

so that if something's in the

13:05

body naturally, whether or not a

13:08

pharmaceutical company tried to claim it, it can be

13:10

sold to the supplement. Wouldn't that like set a

13:12

lot of things free? Yeah, wouldn't it though? Ironically,

13:15

that's one of the reasons why I think

13:17

the FDA hasn't done it. So there's another

13:20

case that's very similar to this with HOMOTORINE,

13:22

if you've ever heard about this one, but

13:24

kind of same, same deal. A company tried

13:26

to take HOMOTORINE, which is a natural molecule

13:29

found in seaweed down the IND pathway. It

13:32

showed really great cognitive enhancement for

13:34

Alzheimer's and specifically the APOE genotype,

13:36

like 33 % in cognition enhancement,

13:38

but still didn't reach the threshold

13:41

that it needed to be for

13:43

being a drug. So

13:45

then the parent company tried to then,

13:47

you know, appeal to the FDA and

13:49

say, hey, it's still a natural molecule.

13:51

It has these great beneficial effects on

13:53

cognition. Can we please sell it to

13:55

the supplement? And the FDA was basically

13:57

like, no, you can't do that out

13:59

of this very hyper technical rationale. The

14:01

FDA doesn't like competition from a short

14:03

notice. Well, I would say they

14:05

didn't. It's shifting now. Similar thing with

14:08

anandamide. and undermine the compound that's in

14:10

tobacco that reverses autoimmunity and Hashimoto's and

14:12

all kinds of people that they they're

14:14

actually preventing my God -given right to

14:17

use whatever the hell I want in

14:19

my body to improve my health and

14:21

like I didn't I didn't hire them

14:23

to do that So this is why

14:25

a lot of people will leave the

14:28

US to do advanced lung debbie treatments

14:30

right now, right? And I think it's

14:32

going to shift And also, there's lots

14:34

of stuff that does work because we're

14:37

routing around FDA roadblocks to human progress.

14:39

Mimeo is four things, 96 % in

14:42

yeast. How does that translate? So if

14:44

something in yeast is 96%, we take

14:46

it into mice, is it to be

14:48

like 30 % on average? How does

14:50

that work? Yeah, it's a great question.

14:52

It really depends on a case -by

14:54

-case basis and how the molecules operate

14:56

within each other. In our case, we

14:58

kind of take a different approach than

15:00

most other longevity pathways. So usually how

15:02

it goes is you make your initial

15:04

discovery in the worms or in the

15:06

flies or in the lower. organisms, right?

15:08

And then you kind of hope that

15:10

it translates up into mice, and then

15:12

you kind of hope that it translates

15:14

up into humans. In our case, we

15:16

do more of a top -down approach.

15:18

We start our discovery process in humans,

15:20

right, studying this

15:22

longevity bioprogram, and

15:24

then found our formulation from there, and then

15:26

basically confirmed that it would have these lifespan

15:28

extension and longevity effects within the C. elegans.

15:30

Oh, that's cool. And you can only do

15:33

this because of AI and big data and

15:35

bioinformatics and all the stuff that came online

15:37

in the last 10 years. Yeah. It's like,

15:39

okay, what do the humans who get benefits

15:41

look like? And then you engineer the molecule

15:43

and then you test it on mice. But

15:45

if you go back 10 years, they would

15:47

have just actually do it on yeast and

15:50

then mice. 10 years ago, they would have

15:52

said, let's just screen whole bunch of random

15:54

compounds on yeast and hope they work in

15:56

human. Exactly. And it's really

15:58

funny because The first compound

16:00

that was a fasting memetic that

16:02

I'm aware of was Metformin. In

16:05

2003, a biomarker Pharmaceuticals came out

16:07

and they said, well, we tested

16:09

on mice and it turns on

16:11

genes same as fasting. And

16:13

so I started taking it back then because we're being really

16:15

long to have a guy. That's what I do. And

16:18

two years later, I met with the

16:20

research team at biomarker just in Palo Alto

16:22

and They are looking at me and

16:24

I'm asking all these questions like, who

16:26

is this weird guy? Like he's not

16:28

even old and he's a computer hacker. And

16:31

so I've been taking it for two

16:33

years. I'm a foreman for longevity and

16:35

they just looked at each other. And

16:37

they're like, can we ask how old you

16:40

are? And I looked at him and I

16:42

said, yeah, I'm 68 years old. And I

16:44

was like, maybe 30 or whatever. And

16:46

they also, it works. I'm like, sorry,

16:48

guys. It's not really, I kind of

16:50

felt bad because they believe me. And I quit after

16:52

a couple of years. I don't

16:54

think metformin is a great thing to

16:57

take unless you have diabetes or something

16:59

because there's just other ways that work

17:01

better. Yeah. But that was the first

17:03

one and it was so hard. I

17:05

mean, that was 20, good God, 22

17:07

years ago when that kind of stuff

17:10

was coming out. What's happening today at

17:12

Mimeo with AI and with extending your

17:14

formulas that you couldn't do five years

17:16

ago? Yeah, that's a great question. So

17:19

what we do with Mimeo is that

17:21

we take this biomimetic approach. So we

17:24

want to solve a problem in humans, I'm

17:26

a very firm believer that you should start

17:28

by studying humans. And

17:30

nature has given us a lot

17:32

of these very interesting regenerative states

17:34

of the body, regenerative pathways that

17:37

our body naturally uses to heal

17:39

ourselves. All the

17:41

plant molecules that are out

17:43

there that come from extracts

17:45

of fungi or yeast or

17:47

some kind of plant. Those

17:50

are the molecules that were designed by that

17:52

plant to heal that plant, and sometimes they

17:54

work for us too. Human

17:57

molecules were designed through tens of

17:59

thousands of years of evolution to

18:01

work on this human operating system

18:03

that we have. So these molecules

18:05

are designed to heal ourselves. So

18:07

what we do is we look

18:09

at these interesting regenerative states like

18:12

fasting or cold exposure or sleep

18:14

or exercise. And then

18:16

we see how the body

18:18

up regulates and down regulates

18:20

certain molecules to achieve these

18:22

beneficial regenerative effects. And

18:24

that's kind of how we develop our

18:26

formulations. We take what nature is already

18:28

doing and then just kind of recreate

18:31

it so you can get those same

18:33

benefits on demand. Biohacking

18:37

is all about improving how you show

18:39

up as a human being at all

18:41

the different levels. And that could

18:43

be hard because sometimes you need to make your

18:45

cells work better or you're working on fear or

18:47

something like that. And anything that

18:50

works is fair game in my

18:52

world. And one of the things

18:54

that does work is affecting your

18:56

body at the quantum level. You

18:59

can get a PhD in quantum biology. We

19:01

know your brain is a quantum system that's

19:04

actually entangled with your heart. We

19:06

know that all the microtubules in your

19:08

body work on quantum effects. We just

19:11

don't see those with our rational human

19:13

brains because the quantum reality behind everything

19:15

is hard to even think about with

19:17

our brains. But it's real. That means

19:20

you can hack it. And one of

19:22

the things I've worked with for months

19:24

now is called quantum upgrade. This isn't

19:27

just another trend. They've got 21 independent

19:29

studies showing results. In

19:31

controlled studies, quantum upgrade users get

19:33

better cellular function within minutes of

19:36

turning it on. Better

19:38

ATP production, better blood markers, and

19:40

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20:02

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20:06

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20:09

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20:11

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22:33

There's a couple of compounds that I

22:35

am fascinated with. This is not part

22:37

of your current formula, but I know

22:39

how you think because you're doing some

22:42

cool stuff. One is PGC -1 alpha,

22:44

which is something that's produced from exercise

22:46

and it's funny this weird thing called

22:48

nicotine raises that. Probably niacinamide a little

22:50

bit, does it? Yeah, niacinamide

22:52

does a little bit for sure. And

22:55

then the other one that is probably

22:57

the most profound that you can get

23:00

today is GW501 -516, also known as

23:02

Cartering. You ever play around with that

23:04

stuff? I actually haven't heard about this.

23:06

Oh my gosh. It causes you to

23:08

grow new mitochondria. It makes your mitochondria

23:10

work better and raises a PGC1 alpha.

23:12

Interesting. It's the closest thing to exercise

23:15

in a pill. Well, people

23:17

call it a sarm. It's not. It

23:19

gets lumped in with sarms. But

23:23

it, of course, like all

23:25

useful substances was banned by

23:27

the exercise bodies. I

23:30

just signed the Declaration on Human

23:32

Enhancement. That's behind the Enhance Games.

23:34

I was one of the signatories

23:36

and gave a talk to a

23:38

couple hundred. big researchers

23:40

from universities. And my guys, when I

23:42

was really sick with chronic fatigue and

23:44

my mitochondrial networks were shutting down and

23:46

I just wrecked, I went to the

23:48

list of band substances because I know

23:50

they work. And they're like, Oh, like

23:53

that's kind of real. And sure it

23:55

is. So these are the things where

23:57

I look at what you have with

23:59

your knowledge, just because of what you

24:01

studied and your frame on reality is

24:03

very different than most researchers. You're like,

24:05

you're human first, you're big data first,

24:07

and If we do that, and so

24:09

what does someone look like after they

24:11

lift heavy after they're doing hit? And

24:14

you say, okay, this is that. How do

24:16

I just turn on those switches? That's

24:19

kind of mind blowing. Yeah,

24:22

absolutely. I mean, when you really break

24:24

it down and think about humans, you

24:26

can kind of think about if this

24:28

is like big chemical computers, right? If

24:31

you put the right inputs in the

24:33

software, it can run a program on

24:35

your hardware. That'll tell it to do

24:37

a specific thing. And it's hard to

24:39

totally encapsulate that because, of course, when

24:42

you're looking at it from a natural

24:44

biology point of view, you have hundreds

24:46

or thousands of processes and molecules that

24:48

are all working in conjunction. and exactly

24:50

the same time to do a specific

24:53

thing, but... when you can start to

24:55

break that down and be like, all

24:57

right, what's really important here, then you

24:59

can kind of get at, all right,

25:01

at least this I can activate and

25:03

this effect I can activate and the

25:06

metabolic efficiency and the autophagy and the

25:08

NAD cert pathway and the AMBK, I

25:10

can do all of that at once

25:12

to better create this, you know, fasting

25:14

longevity bio program. And then as we

25:17

progress through our research and our product

25:19

development, we'll just kind of continue to

25:21

make our formulation more robust and then,

25:23

you know, develop new ones in these

25:25

other states like exercise. If I start

25:28

taking Mimeo, this carefully constructed blend of

25:30

four things, can I stop

25:32

fasting? I

25:34

haven't, I can definitely say that, but

25:36

I can say it, like it makes

25:38

fasting a lot easier and it can

25:41

help to accelerate your benefits, right? So

25:43

Mimeo was designed from a 36 hour

25:45

fast. So if you are doing

25:47

something less than a 36 hour fast, Mimeo

25:49

can really help you to kind of accelerate

25:51

those benefits. Like autophagy is a big one,

25:54

right? Autophagy is one of those benefits that

25:56

doesn't really show up until around, you know,

25:58

24 hours of fasting. And that's just where

26:00

it starts, right? to

26:02

fully deplete your glycogen stores in order to

26:04

get to that metabolic switch and usually it

26:06

takes 20 to 24 hours to do that.

26:08

So if you're fasting for, you know, like

26:10

I do one meal a day now because

26:12

that fits in with my lifestyle. A

26:15

mimeo is really helpful for that because

26:17

it has the oleoethanolamide that's in there.

26:19

That's part of the gut brain axis.

26:22

Stimulates satiety, helps to suppress appetite.

26:25

The PEA that's in there has these

26:27

cognition enhancement effects, really profound effects on

26:29

neuroinflammation, pain relief. It's kind of like

26:31

your body's natural CBD, right? Because it's

26:33

part of the endocannabinoid system, stimulates through

26:36

CB1, CB2 receptors. So that mental clarity,

26:38

that energy, that sharpness. And alongside appetite

26:40

suppression just really gets you through the

26:42

full day. And then by the time,

26:44

you know, my one meal a day

26:46

rolls around, I'm like, perfect. This is

26:48

exactly what I need. And I didn't

26:50

feel like I was missing out on

26:53

anything. And I know that I'm getting

26:55

these stronger fasting benefits because I'm, you

26:57

know, basically taking it up to 11.

26:59

PA is an interesting molecule. It acts

27:01

a lot like low dose naltrexone for

27:03

turning off neuro inflammation. It's something I've,

27:05

I think I wrote about it in

27:07

my cognitive enhancement book and certainly I

27:10

use it regularly. And

27:12

I don't know much about what

27:14

we're called OEA. Yeah, sure. And

27:17

I do know that excessive olive

27:19

oil or oleic acid can have

27:21

a downside, right? Because it turns

27:23

up the inflammatory process for little

27:25

acid. So their megasix has become

27:28

more oxidized when you have more

27:30

than probably 30, 40 grams of

27:32

olive oil, which contains some amount

27:34

of oleic acid. But what you're

27:37

using is a metabolite of oleic

27:39

acid. Correct. How does that stuff

27:41

work? OEA is very

27:43

cool. It is a metabolite of oleic

27:45

acid. It's not a nutrient

27:48

in and of itself like oleic

27:50

acid is. Your body doesn't use

27:52

OEA for energy. It uses it

27:54

as a bioactive signaling molecule. What's

27:56

really interesting when you look at the...

27:58

research history of OEA is that it

28:00

was originally found to be a satiety

28:02

factor. So it was upregulated when people

28:04

would eat and usually when they would

28:06

eat like a big lipid heavy meal,

28:09

which makes sense, right? You're taking in

28:11

food, your body's telling you, all right,

28:13

we've gotten a lot of lipids. We're

28:15

going to convert it to OEA. That's

28:17

going to tell you that we're getting

28:19

full. Stop eating. What we

28:21

found in our study with the 36

28:23

-hour fasting, which no one had really

28:25

known before, was that OEA is, yes,

28:27

up -regulated when you eat, but it's

28:29

really highly up -regulated when you fast.

28:32

And that makes a lot of sense

28:34

from an evolutionary point of view, right?

28:36

When you get to these later stages

28:38

of fasting, your body's gonna be focusing

28:40

on cognition. It's not... know, serving anyone

28:42

to constantly be putting you in hunger

28:44

pangs that you like, you know, can't

28:47

move around with. So it's going to

28:49

naturally suppress your appetite so that you

28:51

can then focus better on finding food

28:53

or hunting down that gazelle, right? So

28:56

OEA is kind of, you know,

28:58

one of our body's natural mechanisms

29:00

for appetite suppression, but then also

29:03

stimulates through P par alpha to

29:05

promote, you know, lipidoxidation, mitochondrial health,

29:07

and then have these kind of

29:10

craving effects on the

29:12

brain as well so that you're decreasing

29:14

cravings. You're not as focused on what

29:16

am I, you know, what am I

29:19

trying to get out of the food

29:21

and more like, okay, let's just find

29:23

it. Let's just be focused. Let's be

29:25

dialed in. That's really cool. And this

29:28

is a compound I think no one

29:30

knows anything about. And it's, it's one

29:32

of these. Have you tested using only

29:34

OEA or only PEA to see what

29:37

it does compared to the MIMEO mix

29:39

they have? We have done that on

29:41

a cellular and organismal level. And there

29:43

are lots of clinical studies with... polymethyloethanolamide

29:46

and oleoethanolamide on their own. The nice

29:49

thing about the MIMEO formulation is that

29:51

in addition to the clinical studies that

29:53

we've done on the full formulation, the

29:55

individual ingredients have like 100 plus clinical

29:57

studies out there already on them showing

30:00

how you have all these various effects.

30:02

But what we found was for the

30:04

lifespan extension, for example, PEA

30:06

was able to extend lifespan by

30:08

24%. OEA was able to extend

30:10

lifespan in that same range, like

30:13

28%. But

30:15

together, those synergistic effects

30:17

got it to the 96 % mark.

30:20

But the really cool thing about

30:22

the PEA and the OEA and

30:24

these like lipid modulators, the endocannabinoid

30:26

system, is that they operate at

30:28

really small levels, right? So we

30:31

can do something with PEA and

30:33

OEA in like the 10 micromolar

30:35

range and still get this big

30:37

36%, or sorry, 28 % lifespan

30:40

extension. That's

30:42

very impactful because a lot of the

30:44

problems that we have with other molecules

30:46

that are more water -soluble is that

30:48

you need them in really high doses.

30:50

You need them like gram levels in

30:52

order to achieve things and that becomes

30:54

really hard on a day -to -day

30:56

intervention. One of my

30:59

biohacking fetishes is MTOR. Sure.

31:04

Talk about MTOR, what does fasting

31:06

do for MTOR and then what

31:08

does MIMIO do for it? mTOR

31:12

mammalian target of rapamycin. It's probably

31:14

one of the primary growth forward

31:16

pathways in the body really stimulated

31:18

by protein intake, insulin, glucose levels.

31:21

Like if you have a bunch

31:23

of nutrients around, but a particularly

31:25

protein, that's what's going to be

31:27

stimulating mTOR. And that's going to

31:29

tell your cells basically

31:31

to grow, replicate, and

31:34

divide. So it's very

31:36

good for muscle building. It's very necessary

31:38

for muscle building. It's also very good

31:40

for, you know, necessary self -replication and

31:42

division. But the problem is when you

31:44

over -stimulate mTOR, you get... all of

31:47

this pro -growth pathways, your

31:49

cells start dividing at a more

31:51

rapid rate. And what that does

31:53

is ultimately wear your cells out

31:55

faster. So mTOR is very highly

31:57

associated with decreased lifespan. So if

31:59

you've got a lot of mTOR

32:01

signaling, the organism is probably going

32:03

to live not as long and

32:05

not as great health. Because again,

32:07

you're kind of like running your

32:09

cells ragged, always replicating themselves and

32:11

always turning themselves over to a

32:13

certain degree. Fasting is basically,

32:17

you know, you don't have a lot of

32:19

nutrients that are floating around, right? You don't

32:21

have a lot of protein that's coming in.

32:23

You don't have any protein that's coming in

32:26

at all. So you're not going to be

32:28

stimulating the MTOR. You're going to be stimulating

32:30

more of these energy conservation. Don't replicate. Don't

32:32

divide. Let's focus on cell maintenance and repair

32:34

pathways like AMPKINES and NAD CERT and all

32:37

of that fun stuff. Mimeo

32:39

is actually not really doing

32:41

anything to mTOR itself. It's

32:44

just stimulating these other pathways

32:46

that we were talking about

32:48

with fasting. So the NADSERD,

32:50

the Ampinase, the PPAR alpha.

32:53

So we're not, you know, an

32:56

mTOR down regulator. We're just up

32:58

regulating these other pathways that run

33:00

counter to mTOR and aren't usually

33:02

activated at the same time. I'm

33:05

always torn. Things like

33:08

mTOR, you don't want

33:10

it to be chronically elevated, but if it's

33:12

low all the time, you're going to look

33:14

like a vegan. You won't

33:16

have any muscles. You'll be weak. You'll have low bone

33:18

density, and you probably won't live a long

33:20

time either. Exactly. Insulin's the

33:22

same way. If you have chronically low insulin

33:25

all the time, well, it's called insulin

33:27

-like growth factor for a reason you put on muscle.

33:31

I've seen a lot of people say, oh,

33:33

I'm only going to eat plant -based protein,

33:35

even though it's not very bioavailable, because I'm

33:38

afraid of mTOR. But then I

33:40

looked at, well, what raises mTOR? Carbs.

33:43

Way more than animal protein amino acids

33:45

like methionine or something. So

33:47

I'm like, I'm going to go for the

33:49

most powerful proteins I can get, which are

33:51

animal -based, because they're more bioavailable than better

33:54

amino acids. But then I'll do

33:56

intermittent fasting, so then I have some time without

33:58

mTOR, so you get this beautiful cycling up and

34:00

down. And what you're proposing

34:02

is, especially during the time

34:04

when you're fasting, you

34:06

take Mimeo, which is going to amplify the

34:09

counter mTOR things like mk and sertumens.

34:11

And if that was too technical for you,

34:13

guys, read Superhuman. I go through these pathways

34:15

in detail and how you can use

34:17

mTOR to put muscle on faster and all

34:19

this kind of stuff. Are you on testosterone

34:22

therapy? I'm not on testosterone therapy. Do

34:24

you measure your testosterone? I actually don't do that

34:26

either. Yeah, my quantified self -days are a little

34:28

bit behind me because I'm not in the lab

34:30

constantly as much anymore. But yeah,

34:32

I haven't been measuring. How old are

34:35

you? I'm 34. 34? Okay, cool. So

34:37

if you are eating and fasting and

34:39

sleeping properly, and you don't have too

34:41

much microplastic, and you're not sniffing your

34:44

car noir or axe body spray, you

34:47

look like you probably have some testosterone

34:49

going on. Probably. It's a little good.

34:51

Good for you, man. It's probably time

34:53

to get your numbers, though, so that

34:55

you can keep them there when you're

34:57

50. That's true. OK. One of the

34:59

fun things that we did, so we've

35:01

done a clinical case study with Cedar

35:03

Sinai, the Dave Petrino lab there. And

35:06

what we found was that when people were

35:08

on eight weeks of self -limitation with Nymia,

35:10

we were actually able to raise their testosterone

35:12

levels by 50%. Holy crap. And that's free

35:14

testosterone. That's a big deal. That's a big

35:16

deal. So they went from like six to

35:18

nine. It was pretty crazy. Wow. Although you

35:20

want to be at 20 if you're high.

35:22

It is true. I mean, I'm not saying

35:25

that those are the right levels, but we

35:27

did increase them. That's meaningful. And if you're

35:29

sitting there with a free testosterone of six,

35:32

you're like... have no motivation to anything

35:34

that matters in the world because this

35:36

is it testosterone drives dopamine Right, so

35:39

that means if Mimeo is raising testosterone

35:41

or free testosterone by 50 % You're

35:43

also giving them more dopamine, right, which

35:45

means that they start caring about themselves

35:48

and rolled around them even more and

35:50

being motivated to do things. That's kind

35:52

of a big deal. Yeah, absolutely. And

35:54

I mean, even beyond that, so this

35:57

case study data was really impressive. You

35:59

know, not only were we able to

36:01

raise that testosterone level, but we also

36:04

had a really great impact on a

36:06

lot of these cardiometabolic markers as well.

36:08

So we were able to reduce glucose,

36:10

HV1C, insulin, improve the

36:12

HDL -LDR ratio. And

36:15

then we also looked at biological age

36:17

and got a biological age reduction of

36:19

two and a half years. in just

36:22

eight weeks of supplementation there. Which biological

36:24

age metrics do I? So the one

36:26

that we used for this one was

36:28

the DNA methylation for True. Yeah, exactly.

36:31

But I also like the blood works.

36:33

Those are usually the ones that I

36:36

find to be the most impactful because

36:38

they're actually showing you something that is,

36:40

you know, grounded in the biology of

36:42

some of these risk markers that we

36:44

typically use in a clinical setting. But

36:47

glycan age, I also like a lot.

36:49

Like an age is good and then

36:51

there's a bunch of things to just

36:53

look at ratios and metabolites and even

36:55

nutrients and they all are they're all

36:58

good. They're all valid and It's sort

37:00

of like what I learned in business

37:02

school at Orden You can take a

37:04

balance sheet and you can look at

37:06

it with like 25 different CFO things

37:08

and you can make it say whatever

37:11

you want So there's different lenses and

37:13

what I appreciate about all the longevity

37:15

clock things like this is If you

37:17

look at one, it's suspect. If you

37:19

look at three of them and they

37:22

all line up, you have a really

37:24

good case to say you've actually reduced

37:26

the speed of aging. And

37:28

there's a few, I'll say like Luddite

37:30

doctors out there who are like, wow,

37:32

those clocks aren't scientific because I don't

37:34

believe that it's possible to extend human

37:37

lifespan. Like, well, that might not be

37:39

a scientific way of thinking about it because it sure

37:41

looks like it's possible. And since we can do it

37:43

in mammals, Like, why can't

37:45

we do it in ourselves? Sure.

37:47

I mean, there was just a

37:49

study that came out a couple

37:51

weeks ago. Three -year long study,

37:53

777 patients, and they were looking

37:55

at the impacts of omega -3

37:57

supplementation specifically on biological age. And,

37:59

you know, a three -year study

38:01

with hundreds of people with four

38:03

biological age specifically never been done

38:05

before, right? And they saw that

38:07

omega -3 supplementation could reduce biological

38:09

aging by three months. So nothing,

38:11

you know, Uber crazy. But

38:13

still, it's this big study that's now

38:15

telling us, yes, it is actually possible

38:18

to slow down aging in humans, and

38:20

it might be subtle, but it's there,

38:22

and we can do it. And

38:24

the cool thing is, if you can reduce

38:27

your aging by even just three months, at

38:29

the end of your life, you'll probably be

38:31

happy for that three months, but along the

38:33

way... what they call a health span, and

38:35

you'll just feel better. Even if you're 18

38:37

and you started doing this, you had more

38:40

energy, had more power, you had more cognitive

38:42

function. So there's very little downside to doing

38:44

this. unless there's a side

38:46

effect that no one's noticed from moderate

38:48

omega -3s. Right, exactly. And that's kind

38:51

of the approach that I take with

38:53

longevity, you know? Like, we can think

38:55

about it as this mythological Ponce de

38:57

Leon thing, where we're all out here

38:59

trying to live forever, become immortal, and

39:02

I think that that's the wrong way

39:04

to look at it. The field of

39:06

longevity isn't about immortality, it's about, I

39:08

want to live my life in the

39:10

best health possible and without disease and

39:12

degeneration for as long as I possibly

39:15

can. I've been very open about the

39:17

fact I plan to live to at

39:19

least 180 perfect health get it But

39:21

the real answer is I'd like to

39:23

die at a time and buy a

39:26

method of my choosing Yeah, I bet

39:28

that's the ultimate freedom But it's very

39:30

different than saying I am running away

39:32

from where I'm fighting death Because what

39:34

I've learned in all my consciousness work

39:37

is that when you fight something it

39:39

just gets stronger mm -hmm And this

39:41

is why Mother Teresa years ago Some

39:44

protesters said, will you join us in our

39:46

march against the war, the

39:48

Vietnam War? And she's like, no. And

39:50

then, what do you mean? And she

39:53

said, I'll march for peace, but I

39:55

won't march against the war. Oh, nice.

39:57

And my approach on longevity comes from

39:59

having experienced groups who are very anti

40:01

-death. And I'm like,

40:03

death is the same as being born. We're all going to do it.

40:06

And that could be very triggering for some people.

40:09

And for me, it's like when it's inevitable, so

40:11

I'm not going to fear it. And I'm going

40:14

to do it with grace and elegance when I'm

40:16

ready. And that means I

40:18

need to have all of my systems

40:20

running at their very fullest power so

40:22

I can just live the life I

40:24

want. And it's why biohacking,

40:27

I came up with the word because I

40:29

couldn't get anyone to pay attention to longevity

40:31

or anti -aging unless they were 60 plus.

40:35

I mean, you'll do it by hacking your 34, because

40:37

I got my power, right? And

40:39

it really matters. And it's changed

40:41

my mindset on my own cognitive

40:43

function, on my, even my spiritual

40:46

meditation stuff. Have

40:48

you noticed correlations between the things

40:50

like AMP case or two -ins,

40:52

all the things you're up regulating,

40:55

and your mental or

40:57

your meditation performance? Yeah,

40:59

absolutely. I mean, there's

41:01

plenty of studies out there looking at,

41:03

you know, the impacts of all these

41:06

pathways on cognition and mood and mental

41:08

health and all that. And you definitely,

41:10

you definitely see those correlations, you know,

41:13

when you get into these positions of

41:15

metabolic dysfunction, like any diabetes or obesity

41:17

or things like that, you have declines

41:19

in health across. every metric, right? Your

41:22

metabolism is so tied into everything that's

41:24

happening in the rest of your body

41:26

because every single cell in your body

41:29

has to have these metabolic pathways inside

41:31

of them to be able to use

41:33

nutrients, create energy, burn energy, and actually

41:35

stay alive, right? So I think that

41:38

the metabolic pathways are some of the

41:40

most powerful in the human body. And

41:42

those are the ones that we have,

41:44

ironically, the most control over. So

41:47

that's why I think that this pathway

41:49

forward of looking at, you know, the

41:51

metabolic pathways, the exercise pathway, the fasting

41:53

pathways, those are going to be the

41:56

way that we get to really that

41:58

ultimate biohack, right? Of like, how do

42:00

our cells work? How can we tweak

42:02

around what they're doing, you know, through

42:04

our own methodology? to get them to

42:06

do what we want to do. That's

42:09

so cool. When you

42:11

started looking at fasting, you

42:13

probably had some ideas about

42:16

what metabolic shifts you would

42:18

predict. What was the

42:20

most surprising shift you found?

42:23

I would say a lot

42:25

of it that we found

42:27

was surprising. There's an obvious

42:29

one where it's like fasting

42:31

increases ketones and increases circulating

42:33

free fatty acids. It increases

42:36

some of the protein catabolization

42:38

markers. But there are also

42:40

really interesting things that we

42:42

didn't expect. So fasting, ironically,

42:45

causes a very sharp increase in

42:47

EPA and DHA. which we

42:49

wouldn't have expected because it's not like

42:52

it is an omega -3 supplement where

42:54

you're putting more into the body, but

42:56

it actually causes your body to produce

42:58

its own EPA and DHA or mobilize

43:00

stores, I should say. It's not producing

43:02

it. It's mobilizing its stores of these

43:04

molecules and then upregulating them. And then

43:07

same with like branched chain amino acids.

43:09

You get a really big increase in

43:11

branched chain amino acids, which are actually

43:13

muscle sparing. All right. So those are

43:15

in these early stages of fasting. Kind

43:17

of like we were what we were

43:19

talking about before before you get into

43:22

these later stages that can be very

43:24

much more like a starvation response You

43:26

have this in -between zone where your

43:28

body is doing all the things that

43:30

you want it to do during a

43:32

fast It's going to be mobilizing fat

43:35

while sparing protein while enhancing cognition and

43:37

walls like suppressing hunger and is pressing

43:39

inflammation all these deleterious things so kind

43:41

of getting back to that Reset that

43:43

happens and then you know beyond things

43:46

like that, then a lot

43:48

of the metabolites that we looked at were a

43:50

surprise to us, right? Like OEA was a super

43:52

big surprise because people had only seen it in

43:55

a fed state before and had no idea that

43:57

it was highly upregulated during fasting. More

43:59

like PEA, which is more considered

44:02

to be a rest and recovery

44:04

molecule that's really highly upregulated during

44:06

wound healing or like after a

44:09

traumatic brain injury or things like

44:11

that for it to also be

44:13

elevated during fasting and creating these

44:16

Repair effects was really cool to

44:18

see a lot of biohacking Includes

44:20

circadian biology and the true dark

44:23

glasses I'm wearing started this company

44:25

ten years ago to support circadian

44:27

biology and When I wrote the

44:30

bulletproof diet said look It's

44:32

easiest to skip breakfast because of social

44:34

things. But the peak caloric consumption window

44:37

is from basically noon to 2 p

44:39

.m. Because that's when the sun is

44:41

above us and when we were mitochondria

44:43

floating in the ocean, that was when

44:45

there was the most algae. So

44:48

if you were to really perfectly set up

44:50

your one meal a day, you'd have like

44:52

a big lunch and no breakfast, no dinner,

44:54

but then you'd have no social life and

44:56

no dating and like it sucked. So basically

44:58

just have an early dinner and you'll be

45:00

fine. But with fasting, If you were to

45:02

say, eat all your calories at midnight, instead

45:05

of during the day, you would have an

45:07

unsuccessful fast. How does Mimeo

45:09

and what you're up regulating and

45:11

fasting, how does that tie into

45:13

circadian rhythms? It's a great

45:15

question. We didn't do enough research on our

45:17

end to really look at the circadian pathways

45:19

that were also being affected at the same

45:21

time because we were very well controlled when

45:23

we did our studies. So we looked at

45:26

the same time of day in a baseline

45:28

state, in the same time of day in

45:30

a fasting site, or same time of day

45:32

in a fed state, and the same time

45:34

of day in a refed state. eliminate

45:38

as much of the confounding factors

45:40

as we possibly could. So we

45:42

haven't, as a research group, seen

45:44

a ton of impact on how

45:47

fasting relates to the circadian rhythms

45:49

or if there is a more

45:51

appropriate time to fast or not

45:53

fast. I have definitely seen some

45:56

research. that the number one thing

45:58

setting your central clock is light. And there's

46:00

four colors of light plus two other variables

46:02

that are controlled with those sleep glasses I

46:04

make. And this is why I teach people

46:06

to turn off the lights at night, get

46:08

dimmer switches, get red lights. This is really

46:10

important. And if you want to fix your

46:13

biology, do it. And that's because we know

46:15

you become insulin resistant as melatonin goes up.

46:17

And so with fasting, we're messing with insulin

46:19

levels and all of that. So I know

46:21

that it matters. And we think we know

46:23

the time, we think we know why, which

46:25

is why peak consumption of calories in the

46:27

middle the day would make the most sense

46:29

even though you can wiggle. So given let's

46:31

just pretend that all that is true. It's

46:34

a good theory and it's backed by some good thinking. When

46:37

would be the best time of day

46:39

if you were to predict without having

46:42

a study to take Mimeo? So I

46:44

feel like the best time of day

46:46

to take Mimeo is

46:48

usually in the morning or the

46:50

afternoon. I'll say morning, because since

46:52

these are all fasting metanolites, we

46:54

know that they work better in

46:56

a fasted. You're asleep, so you're

46:58

fasted, so you take them to

47:00

amplify the fast in the morning.

47:02

Okay. Yeah, exactly. And then they'll

47:05

give you those great benefits throughout

47:07

the day. We have also shown

47:09

in clinical studies, though, that you

47:11

can take Mimeo with a meal,

47:13

and it'll give you these fasting

47:15

-like benefits. even when you're eating.

47:17

So we had people come in,

47:19

eat a standardized breakfast alongside a

47:21

placebo control, then looked at their

47:23

plasma functionalities, their cellular functionalities. We

47:25

had those same people come back

47:28

after a washout period, eat

47:30

that same standardized breakfast, but then

47:32

with supplementation with Mimeo. And

47:34

what we found was that when people

47:36

ate the breakfast with the placebo, there

47:38

was this big loss of plasma functionality.

47:40

And that's you know, very typical of

47:43

the postprandial response, right? You've got all

47:45

these foreign molecules that are coming in,

47:47

all these nutrients that are flooding into

47:49

the system, kind of throwing the system

47:51

out of homeostasis, creating all this metabolic

47:53

chaos, immune responses, inflammation, things like that.

47:55

But when they had that same meal,

47:57

but with supplementation with Mimeo, We were

48:00

able to not only prevent all of

48:02

that loss of function, but then add

48:04

gains of function on top of that,

48:06

that mimics what we saw during a

48:08

fast. So instead of being pro -inflammatory,

48:11

their plasma was anti -inflammatory. Instead of

48:13

being pro -oxidant, it was antioxidant. And

48:15

it was much more cardio protective, had

48:18

much better metabolic readouts. So we were

48:20

really, really happy with that, to be

48:22

able to, like, yes, you can take

48:24

this with food, kind of balance out

48:26

these negative impacts of the postprandial state

48:29

and get the is fasting like benefits

48:31

just through supplementation. You could call up

48:33

Kellogg's and just partner with Fruit Loops

48:35

and just have them Mimeo Fruit Loops

48:38

bundles so Fruit Loops won't be as

48:40

bad for you. Yeah, see, there you

48:42

go. Kellogg's. I have to get that

48:44

red number two out of there. This

48:51

leads to the question. If

48:53

it's beneficial to take your fasting memetic

48:55

in the morning, and to skip break

48:58

fast so that I have a longer

49:00

fast. Should I also take it

49:02

when I have my main meal just to make

49:04

sure I don't get punched in the face by

49:06

my meal? Yeah, you can definitely do that if you

49:08

want to. What we found is that people typically don't

49:10

like to take it at the end of the day

49:13

because it does have an energizing effect, right? So we've

49:15

had plenty of people who take it at like six

49:17

or seven o 'clock at night when they were at

49:19

an event with us or something like that. We were

49:22

handing out samples. They took it and they were like,

49:24

wow, I had a great experience. I felt X, Y,

49:26

and Z things, but I did not go to bed

49:28

until two in the morning. Yeah,

49:30

so. It's one of those things. We just typically

49:33

recommend that people take it in the morning. Or,

49:35

yeah, if they're doing more traditional, you know, 16

49:37

-8 style fasting, you can definitely wait until your

49:39

first big meal to take the mimeo with, kind

49:41

of help extend the fast and, yeah, keep your

49:44

meal from punching you in the face. I like

49:46

that. We'll put it on a t -shirt. Nice.

49:49

It's kind of funny because you

49:51

need... mitochondrial action when you're asleep

49:54

to drive the glymphatic system to

49:56

clean out all the toxic brain

49:58

metabolites. And I published a couple

50:00

or references to a couple studies

50:02

and I think that was in

50:04

my brain book. I don't know.

50:07

It could have been in superhuman.

50:09

And so we know that that's

50:11

necessary and we know that you

50:13

get higher sleep efficiency if your

50:15

mitochondria are running at full power.

50:17

But if you become energized via

50:20

other pathways, either your ability to

50:22

go to sleep, your desire to

50:24

go to sleep, or your ability

50:26

to stay asleep will go down.

50:29

And you're saying so kind of latest time to

50:32

take Mimeo would be? I would

50:34

probably say that I wouldn't take it past

50:36

maybe four or five, okay, at night, something

50:38

like that. Got it. Unless a burning man,

50:40

you're going to be up all night, so

50:43

take it. Yeah, exactly. Well, I

50:45

mean, that's ironically, like, we'll

50:47

say this like off the record, don't

50:49

tell nobody. But I like to take

50:51

Mimio if I am going to go

50:53

out and have a big night of

50:55

celebrating or drinking, because in addition to

50:57

all these great fasting -like benefits, the

50:59

PEA and the OEA themselves have great

51:01

cellular repair benefits to them. And

51:04

then PEA and OEA specifically

51:06

have been shown to be

51:09

really helpful for enhancing the

51:11

gut membrane, so increasing gut

51:13

tight junction and barrier functionality,

51:15

as well as in reducing

51:18

specifically alcohol -related. inflammation and

51:20

symptoms of alcohol abuse. So

51:23

they're really good for creating those

51:25

pain relief effects from the PEA and

51:27

then the alcohol inflammation suppression and effects

51:30

and protective effects of the OEA at

51:32

the same time. So I definitely like

51:34

to use it later at night if

51:37

it's going to be a long one

51:39

and next morning feels great. Nicotine.

51:42

That one I come specifically from

51:45

a rheumatoid arthritis lab who did

51:47

research on nicotine specifically and nicotine

51:49

not even in the context of

51:52

cigarettes but nicotine just like it

51:54

has its own and that was

51:56

shown to be you know pro

51:59

-inflammatory and have these negative impacts

52:01

on joint health specifically in a

52:03

rheumatoid arthritis you know context. So,

52:06

for that, for me, it's kind of like,

52:08

I know that there's data on the brain

52:11

side of things, but then I also see

52:13

this conflicting data with inflammation and joint health.

52:15

So, I'm on the fence about it. I'm

52:17

on the fence about it. It's

52:20

likely a dose thing,

52:23

and it's also, there's probably some individual

52:25

biochemistry, and it's funny you go

52:27

back to niacinamide. They're

52:30

activating downstream and

52:33

acetic acid receptors in the brain. I use

52:35

it for neuro protection because I don't want

52:37

Alzheimer's or Parkinson's. And as someone who had

52:39

arthritis since I was 14, in

52:41

my knees and I don't have it anymore,

52:43

I monitor my joints. They seem to be doing

52:45

pretty well. So I'm going to keep doing

52:47

my low dose anti -aging nicotine until I find

52:50

that there's evidence not to. Well, there you

52:52

go. I mean, if all the science and it

52:54

will, it will show you reality. It's also

52:56

good for interviewing and just cognitive functions. So I

52:58

kind of like smart drugs. Yeah. I mean,

53:00

who does it? Do

53:02

you ever track biomarkers with Mimeo

53:05

like galvanic skin response, heart rate,

53:07

variability, body temperature, EEG,

53:09

brainwaving amplitude? Like what information do

53:11

you have about that? So we

53:13

don't have a ton of that

53:15

data. What we do have a

53:17

ton of is blood data. So

53:19

we can see blood markers being

53:21

altered with Mimeo, like we were

53:23

talking about before, like the cardiometabolic

53:25

stuff. We've seen ALT levels go

53:28

down. We've seen biological age shift

53:30

around. We've seen HDL, LDL ratio,

53:32

triglycerides, and glucose insulin, HB1C, what

53:34

have you. And even beyond

53:36

that, we just recently, very excited

53:38

about this, we were doing a

53:41

decentralized clinical study. with people science

53:43

as our third -party CRO and

53:45

just finished that study looking at

53:48

the impacts of eight weeks of

53:50

MIMEO on overweight people with elevated

53:52

HB1C and we're able to show

53:55

that we can modify appetite, really

53:57

suppress that, reduce food noise, reduce

53:59

cravings, increase the tidy. We have

54:02

been able to decrease abdominal pain

54:04

and bloating. reduce

54:07

fasting glucose levels and reduce

54:09

oxidative stress, reduce cholesterol levels,

54:12

improve lipid profiles. So

54:14

really, really enthusiastic about what NIMEO

54:17

can do. And especially like we

54:19

were talking about on those metabolic

54:21

health pathways that are so important

54:23

for just general functioning cognition and,

54:25

you know, longevity in general.

54:27

So Big Pharma hates Mimeo? Yeah, Big Pharma

54:30

will hate Mimeo. But that on a shirt.

54:33

I mean, this is the

54:35

power of using science and

54:37

data and advanced supplementation. It's

54:40

pretty fascinating. It is. No

54:42

one has studied these combinations.

54:45

And one thing that made me want to

54:48

bring it on the show is that a

54:50

lot of companies, a lot of researchers, they

54:52

find like a hero molecule. And

54:54

like David Sinclair, for instance, I

54:57

like David. He's been on the show. He has

54:59

two, which I totally agree. He's like, oh, you're

55:01

a resveratrol in NAD. So let's look at them

55:03

together. And so that's like a first step. But

55:06

you get a lot of the big pharma thinkers

55:08

or traditional thinkers, and they're saying, well, I'm going

55:10

to study this one molecule to see what it

55:12

does. And there's this analogy

55:15

that I think is in at least one

55:17

of my books. But if you were to

55:19

take an FDA researcher and say, I want

55:21

you to test for bread, They'd say, well,

55:23

I baked the yeast, I baked the water,

55:25

I baked the flour, I baked the salt.

55:27

There is no bread. Because you have to

55:29

have a recipe, and longevity is all about

55:32

a personalized recipe for your biology to give

55:34

you more energy now and to extend your

55:36

life. And it's not going to be single

55:38

variable. It can't be. And Biohack

55:40

is like, what are all the variables I could

55:42

play with to get close enough into a symphony

55:44

to make my biology to what I want? And

55:47

you've come up with a four

55:49

-part recipe, funny enough, same as

55:51

bread, that that you're showing

55:53

works for a lot of people. Yep,

55:55

super cool. Now, after

55:57

I wrote the Bulletproof Diet, about four

56:00

or five years later, I'm

56:02

like, God, I see people way

56:04

over -fasting. Like

56:07

Jack Dorsey, super cool guy.

56:10

The guy who said you have Twitter for

56:12

a long time, and he had Bulletproof Coffee

56:14

in his office, and he started doing one

56:16

meal a day. And then he started skipping

56:19

meals on weekends, and it seemed like But

56:22

it seemed like there was a point where he was starting to overfast.

56:24

And then there were people who were just

56:27

blown out like I have been biologically. And

56:29

they're saying, well, some intermittent fasting is good.

56:31

I'm just going to way overfast. And then

56:33

when guys overfast, we end

56:36

up after about maybe six, eight

56:38

weeks, like, oh, that's

56:40

weird. I wake up without a kickstand

56:42

and I can't sleep very well. And

56:44

he was, oh, I've done something that

56:47

wasn't good. And women, it takes less

56:49

time. And they're waking up. frequently at

56:51

night, their sleep goes away, their cycle

56:54

gets wracked, hair starts getting thin in

56:56

both of us. But since women are

56:58

more susceptible to over -fasting, and there's

57:01

a monthly variation in when women benefit

57:03

from fasting, You're saying Mimeo

57:05

works for men and women equally? Does

57:07

this mean women will get more benefits

57:09

from Mimeo than men? Walk me through

57:11

the N versus women fasting difference. It's

57:13

a great question actually, so I can

57:15

do that now. When we did our

57:17

initial fasting study, we were doing it

57:19

with 20 people and we had an

57:21

equal distribution of 10 men and 10

57:23

women to avoid that gender bias. There

57:25

is not enough research. with

57:27

women and fasting. That's the major takeaway

57:29

that we can get from all the

57:32

literature. So we wanted to make sure

57:34

that the changes that we were looking

57:36

at were going to be universal across

57:38

sexes. So what we found from Mimeo

57:41

is, of course, applicable to both. And

57:43

that's what we also see in this

57:45

big randomized double -blind placebo -controlled study

57:47

that we just did. We also had

57:50

an equal proportion of men and women

57:52

gave them Mimeo. And what we saw

57:54

there was that there wasn't any significant

57:56

gender difference. We just saw these good

57:58

improvements in all of these biological markers,

58:01

their appetite suppression, their cravings, their food

58:03

noise, their abdominal pain and bloating, all

58:05

that fun stuff. So, you know, as

58:07

far as we can tell, Mimeo works

58:10

equally well for both men and women

58:12

because we designed it that way. With

58:14

men, we have the years when our

58:16

testosterone is adequate, and then we have

58:19

years of andropause, called grumpy old men,

58:21

unless we do something about it. And

58:24

with women, you have the years when

58:26

you're cycling, you have perimenopause, and then

58:28

you have menopause. And what works is

58:30

pretty different during those things. Absolutely. For

58:32

the women in your study, did you

58:34

mix the three stages? Were they all

58:36

young? Were they all middle -aged? What

58:38

was the lack? Yeah, for the initial

58:40

study, they were actually all young. So

58:43

they were all pre -menopausal women. That's

58:45

what we were looking at. In this

58:47

latest study, we were looking at older

58:49

overweight people. So all the women were

58:51

post -menopausal. So, you know, we've looked

58:53

at women and both say we haven't

58:55

hit paramanipause yet because that's still like

58:57

a very much an evolving state that's

58:59

kind of new to the scientific lexicon.

59:02

But yeah, we try to get as

59:04

big of a swath and as equal

59:06

of a swath as we can when

59:08

we're doing our research. In Fast This

59:10

Way, my second book to kind of

59:12

correct the amplifications of the fasting strategies

59:14

in the first book, there's a chapter

59:16

where I pulled all of the research

59:18

on women together. And one

59:20

of the studies that stood out the most

59:23

was that for menopausal women, there's

59:25

an Australian study and a good -sized one,

59:28

the benefits start at 12 hour fasts

59:30

three times a week. Okay. That is

59:32

really tiny. Yeah, basically. You just have

59:34

a late breakfast three times a week,

59:36

and they probably scale up to 18

59:38

hours and probably more than that. But

59:41

the idea here, if you're listening,

59:43

Saying, oh, I'm in menopause or

59:45

maybe my mom's in menopause. You

59:47

don't have to be a crazy

59:49

faster to get benefits just from

59:51

intermittent fasting. And if you

59:54

have something like Mimeo that amplifies the

59:56

effects of that, you might literally say,

59:58

I wait till 10 to have breakfast.

1:00:00

I take my Mimeo and I wake

1:00:02

up and you're getting meaningful benefits that

1:00:04

include not really having cravings. This

1:00:06

is kind of a big deal. I'm

1:00:09

intrigued. I mean, so my COO, Kamin Beatty,

1:00:11

who also happens to be my sister, she

1:00:13

uses Mimeo specifically for that purpose, right? Like

1:00:15

before, you know, she was of course aware

1:00:17

of all the fasting stuff that was going

1:00:19

on because it was a big part of

1:00:21

my lifestyle, but she never really embraced it

1:00:24

all that much up until we like started

1:00:26

forming Mimeo and she started to get into

1:00:28

it there. And she found it really difficult

1:00:30

before we had first prototypes to get it.

1:00:33

And to really be able to extend her

1:00:35

fast beyond that kind of, you know, 12

1:00:37

or 16 hour mark. But then once we

1:00:39

actually had the prototypes of Mimeo, we could

1:00:41

take the product and we could see how

1:00:43

it works. She found that she had no

1:00:45

problem doing it. You know, she's done a

1:00:47

full day fast up to 36 hours now.

1:00:49

And was like, oh yeah, I just wasn't

1:00:51

even thinking about it because I was on

1:00:53

my Mimeo and I had other stuff I

1:00:55

was doing that day and it just kind

1:00:58

of happened. And it really empowered her because

1:01:00

it's one of those things. It's the same

1:01:02

for me. We are told this story. over

1:01:04

and over and over again in Western nutrition

1:01:06

where it's like three meals a day plus

1:01:08

snacks like if you are hungry it means

1:01:10

that your body is eating itself like you

1:01:12

should never be in mind because of hunger

1:01:14

and I think that that's a very very

1:01:16

damaging message because it leads to this kind

1:01:18

of chronic dietary inflammation this chronic dietary fatigue

1:01:20

that we all get into it takes the

1:01:23

body around four to six hours after a

1:01:25

meal to return back to baseline

1:01:27

to get out of the post -prandial state.

1:01:30

And if we're doing three meals a

1:01:32

day plus snacks, we're basically never getting

1:01:34

out of that fed state. It's always

1:01:36

just kind of stacking and stacking and

1:01:38

stacking until we finally like sleep and

1:01:41

fast and let our body return homeostasis

1:01:43

and do its cellular repair and all

1:01:45

of that stuff. So to be able

1:01:47

to go a full day without eating

1:01:49

and not die. was like

1:01:52

a really big revelation, right? It's like everything

1:01:54

that I ever learned is wrong, right? And

1:01:56

there's this better way to do things that

1:01:58

can work with your lifestyle better, that can

1:02:00

make you healthier, and can

1:02:02

just really help you have a better

1:02:05

relationship with food in general. If you're

1:02:07

using a fasting memetic like Mimeo, does

1:02:09

that mean you can eat more carbs

1:02:12

when you do eat? Hmm. What a

1:02:14

good question. Usually what we tell people

1:02:16

with Mimeo is that we can't guarantee

1:02:18

that we'll make you healthy, but we

1:02:21

can guarantee that we'll make you healthy,

1:02:23

right? Mimeo is not

1:02:25

going to be, you know, a magic

1:02:27

bullet that's going to allow you to

1:02:30

like, okay, cool. And now I can

1:02:32

just eat donuts forever and take Mimeo

1:02:34

and that will be fine. Right. We

1:02:37

still recommend that. I still fast. I

1:02:39

still eat well. And I take Mimeo

1:02:41

in order to get the maximize benefits

1:02:44

of all of that. So it's not,

1:02:46

it's not something. that's going to be

1:02:48

this total metabolic shift game changer kind

1:02:51

of thing, but it will really help

1:02:53

you, like we said, kind of establish

1:02:55

more of that natural homeostasis where if

1:02:58

you are stimulating these fed pathways constantly

1:03:00

with that Western diet, three meals a

1:03:02

day plus snacks, we're also going to

1:03:05

be helping you elevate these beneficial fasting

1:03:07

ones that you're not going to experience

1:03:09

in that time zone so that you

1:03:12

can balance things out. The closest I've

1:03:14

seen to the eat donuts every day

1:03:16

and live a long time is Sandy

1:03:19

Coffman who's been on the show. She's

1:03:22

a friend and a medical doctor and

1:03:24

longevity doctor and kind of crazy in

1:03:26

a good way. And I have been

1:03:28

out to dinner with her and she's

1:03:30

like, I'll have the cupcake. And

1:03:33

I'm like, are you kidding me? And every

1:03:35

time she's in us and she goes to

1:03:38

these cupcake vending machines. You're

1:03:40

really going to do that. He just regularly

1:03:42

says, yeah. So I just block all the

1:03:44

effects of all of the bad things sugar

1:03:46

does because I like it. And

1:03:48

I'm not that far, but I'm not

1:03:51

opposed to using pharmaceutical molecules or natural

1:03:53

molecules to extend my life. I'll do

1:03:55

whatever. But I kind of

1:03:57

like the idea if I knew with

1:03:59

certainty that I could eat absolute junk

1:04:01

food and feel amazing and maintain all

1:04:03

of my health and longevity, I

1:04:06

wouldn't mind the cheesecake diet. Yeah. No, yeah,

1:04:08

of course not. Who would? Do you think

1:04:10

we're gonna get there? I hope so. One

1:04:12

day. I mean, there are some really cool

1:04:14

technologies that are coming out. So like, you

1:04:16

know, Mimeo comes from a biotech background. We

1:04:18

were in the IndieBio accelerator program, which is

1:04:21

basically like Y Combinator, but for biotech. And

1:04:23

there's a lot of like nutrition, food and

1:04:25

ag technologies that are coming out of that

1:04:27

program. So we've gotten to see and meet

1:04:29

people who are doing some really interesting

1:04:32

stuff, including calorie absorption technology, right? So

1:04:34

basically, you would take this thing alongside

1:04:36

food, and it kind of sucks up

1:04:38

the nutrients, the glucose, the proteins, the

1:04:40

lipids, whatever into this non digestible fiber

1:04:43

matrix, and then just passes it right

1:04:45

through your system, right? So I think

1:04:47

that, you know, as we progress, and

1:04:49

as we progress, you know, forward at

1:04:51

a really rapid rate, now that we're

1:04:54

in the era of big data and

1:04:56

AI that It's really going to be

1:04:58

a lot of game changers are going

1:05:00

to come down the pipe pretty soon.

1:05:02

I look forward to the day when

1:05:05

there's an antidote for every type of

1:05:07

food that isn't good for me. So

1:05:10

I'm like, today is going to be

1:05:12

gluten, dairy, canola oil,

1:05:14

glyphosate, whatever. And

1:05:16

I pop a pill or shine a light

1:05:19

in my earlobe or whatever the hell it

1:05:21

ends up being. And it has no negative

1:05:23

effects. Yeah. I'm just, my diet today is

1:05:25

going to be all oxidized canola oil and

1:05:27

I'm going to feel great. Yeah. I think

1:05:29

it doesn't taste good once you're used to

1:05:32

real food. So I would just eat probably

1:05:34

all croissants and grass fed steak anyway. But

1:05:36

that is a, that is a very good

1:05:38

choice. Mine would be Trace Leche's cake. That's

1:05:40

my favorite thing. Oh man. I'm someone who's

1:05:42

definitely cow dairy sensitivist. It goes into casey

1:05:45

and morphine in my system. It's like, it's

1:05:47

like taking Valium. I become just unable to

1:05:49

think I drool on myself. And then my

1:05:51

gut is wrecked. And gluten does a similar

1:05:53

thing. Well, at least American gluten. I seem

1:05:55

to handle European gluten, alright. But

1:05:57

Isaiah, that works. That combination, to me,

1:06:00

is the worst kryptonite ever. Oh yeah.

1:06:02

But tress leches is the most delicious

1:06:04

thing you could ever eat. So,

1:06:06

that ain't that always the way. It's

1:06:08

not fair. So come up with that,

1:06:11

Mimeo. Would you? Well, yeah, you know,

1:06:13

we'll work on it. Yeah, just let's

1:06:15

just antidote. I would spend a lot

1:06:17

on that. So specifically, for no other

1:06:20

purpose, just sat. Right, yeah. Put

1:06:22

on your future hat. And let's say that

1:06:24

you continue with what you're doing with Mimeo,

1:06:27

and fasting becomes entirely optional

1:06:29

for humans. Would we

1:06:31

lose something? Like, is there something about fasting

1:06:33

that just in and of itself is good

1:06:35

for us? Yes, I definitely think that there

1:06:37

is something about fasting in and of itself

1:06:40

that's good for us, for sure. Because,

1:06:42

like we were talking about before, there's

1:06:44

this element of empowerment that comes along

1:06:46

with fasting, right? To be in control

1:06:49

of your body in that way, and

1:06:51

to be able to exit out of

1:06:53

some of the societal philosophies and like

1:06:55

edicts that have been you know brainwashed

1:06:57

and burnt into us since we were

1:06:59

kids like the nutrition pyramid and the

1:07:01

three meal a day plus snacks kind

1:07:03

of um kind of western diet stuff

1:07:06

that we know about when you can

1:07:08

break that cycle through fasting i think

1:07:10

that that's just very cognitively empowering very

1:07:12

philosophically and spiritually empowering right to be

1:07:14

able to say that i can control

1:07:16

my body i know what my actual

1:07:18

limits are and if i don't Want

1:07:20

to eat if there's something in front

1:07:23

of me that it's like oh someone

1:07:25

brought in pizza, right? So the office

1:07:27

party like I don't actually have to

1:07:29

eat that pizza It's just that it's

1:07:31

noon doesn't mean that I have to

1:07:33

do it so I can you know

1:07:35

have more of that control of myself

1:07:38

that better food relationship and Yeah, be

1:07:40

be in charge of your own metabolic

1:07:42

destiny. There's a sense of

1:07:44

inner peace that does happen from learning

1:07:46

how to fast. Because some of

1:07:48

the research I found says about a third of

1:07:51

the average person's thoughts every day are about what's

1:07:53

for the next meal. Yeah. So if a third

1:07:55

of my thoughts are about tacos, they're

1:07:57

not about extending my life. They're not

1:07:59

about being kind. They're not about improving

1:08:02

anything in the world. They're literally about

1:08:04

tacos or tres leches. So

1:08:06

that's not a functional state of

1:08:08

being, which means I've got to

1:08:10

make peace. with my

1:08:13

operating systems desire to eat food and to

1:08:15

tell it to chill out, you're not gonna

1:08:17

die. And if we were to say, well,

1:08:19

you know, I have to eat all the

1:08:21

time and I can if I don't need

1:08:23

harm, the having to do it

1:08:25

part still is not a good thing for

1:08:27

humans. So it's like, I'm okay if I'm

1:08:29

not in a fed state. I'm okay if

1:08:32

I'm in a fed state and either one's

1:08:34

just fine. That's a great piece of learning.

1:08:36

Yeah, exactly. And that is something that also

1:08:38

kind of happens a little bit biologically too.

1:08:41

You get into this state once you get

1:08:43

adapted to fasting where you do kind of

1:08:45

get this separation between you and your hunger

1:08:48

responses where it's just like you said, it's

1:08:50

like, I'm totally fine when I'm fasting and

1:08:52

totally fine when I'm fed and I appreciate

1:08:54

the differences between them too, but I'm not

1:08:57

obsessed with them anymore. It's just like, I

1:08:59

don't really feel hunger all that much on

1:09:01

a day to day basis anymore. Chris,

1:09:04

you're Researchers at MimeoHealth.com,

1:09:06

M -I -M -I -O, health.com,

1:09:09

and that's where your fascinement medic

1:09:11

is as well. Now,

1:09:13

when people come on the show and talk about their

1:09:15

cool stuff, I usually say, you're going to give listeners

1:09:17

a little bit of a discount here. Are you up

1:09:20

for giving us a discount code? Oh, yeah, absolutely. Okay,

1:09:22

cool. We didn't prep those at a time at all.

1:09:24

I just like doing cool stuff. What do you want

1:09:26

to make it? I think we already have it. I

1:09:28

think it's just Dave. There you are, guys. Make sure

1:09:30

your team turns that on. It's going to be Dave

1:09:32

is the discount code MimeoHealth.com, 20 % off. And

1:09:36

there's real science to this. And a lot

1:09:38

of times people are saying, well, David, you're

1:09:40

always promoting something. Yeah, I'm always promoting living

1:09:42

as long as you want and feeling amazing.

1:09:44

And there's all sorts of cool stuff out

1:09:46

there. And this is very data -driven. This

1:09:49

is PhD -level stuff. It's big data stuff.

1:09:51

And fasting memetics are real. And kind of

1:09:54

a big deal in the fasting space. I've

1:09:57

taught 100 ,000 people with the fasting challenge

1:09:59

I do. I think that's fastwithdave.com. It

1:10:02

matters for peace inside of you and

1:10:04

anything that makes it easier to fast.

1:10:06

I don't care if it's putting butter

1:10:08

in your coffee or if it's Mimeo

1:10:10

or some breath work. It's important that

1:10:13

all humans learn how to go 24

1:10:15

hours without food without losing their shit.

1:10:17

Like, that's really important. Absolutely. And

1:10:19

your supplement will do that. And I think

1:10:21

there's enough evidence behind what you're doing that

1:10:23

Mimeo's in my stack. That's totally fine. Yeah,

1:10:25

I love that. Yeah, I appreciate it. Guys,

1:10:27

if you like today's episode, you know what

1:10:29

to do. Step away from the taco. That's

1:10:32

the end of the next one. See you

1:10:34

next time on the human

1:10:36

upgrade podcast. Before

1:10:54

using any products referenced on the podcast, consult

1:10:57

with your healthcare provider. Carefully read all labels

1:10:59

and heed all directions and cautions that accompany

1:11:01

the products. Information found or received through the

1:11:03

podcast should not be used in place of

1:11:05

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1:11:08

If you suspect you have a medical problem

1:11:10

or should you have any healthcare questions, please

1:11:12

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1:11:14

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1:11:17

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1:11:19

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1:11:21

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1:11:23

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